111例男性不育症患者细胞遗传学分析  

Analysis of cytogenetic in 111 male infertile patients

作　　者：马宁 杨晓 彭薇 李昊 王艳 

机构地区：[1]中国人民解放军陆军总医院附属八一儿童医院发育生物学实验室出生缺陷防控关键技术国家工程实验室儿童器官功能衰竭北京市重点实验室,北京100700

出　　处：《中国优生与遗传杂志》2018年第2期53-54,70,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨男性不育与染色体核型的关系。方法对2015年1月-2017年6月在陆军总医院就诊的111名男性不育患者根据精液参数分成3组,分别为:精液正常组,少弱精症组和无精子症组,分析各组染色体的畸变率及特点。结果少弱精子症组和无精子症组染色体畸变率分别为39.39%和54.29%,少弱精症组和无精子症组染色体畸变率染色体多态性的发生率分别为21.21%和8.57%,均高于精液正常组,差异均有统计学意义。结论染色体畸变是导致男性不育的主要原因之一。携带染色体多态性的男性不育症患者需要作进一步的分子遗传学分析,以明确病因。Objective：To investigate the influence of chromosomal karyotypes male infertility.Methods：Based on semen parameters,111 Male infertile patients from January 2015 to June 2017 at PLA Army Beijing General Hospital were divided into three sub-categories：azoospermia group,oligo-or astheno-spermia group,normal semen parameters group. Chromosomal karyotyping were carried out for all patients in three groups. Results：The chromosome abnormality rate of patients in azoospermia group（39.39%）and oligo-or astheno-spermia group（54.29%）was significantly higher than that of in normal semen parameters group（4.65%）.The incidence of chromosomal polymorphisms in azoospermia group（21.21%）and oligo-or astheno-spermia group（8.57%）also was significantly higher than that of in normal semen parameters group（2.33%）. Conclusions：Chromosome abnormality is one of major causes of male infertile. Molecular genentic analysis should be carried out in male infertility patients with chromosomal polymorphisms.

关 键 词：男性不育 精液分析 染色体畸变 染色体多态性 

分 类 号：R698.2[医药卫生—泌尿科学]