贲门高级别上皮内瘤变患者血清血小板因子4表达及其临床意义  

Expression of serum platelet factor 4 in high-grade intraepithelial neoplasia of gastric cardia and itsclinical significance

作　　者：陈仙梅 高瑞萍[1] 郭硕[2] 袁丽[2] 张立玮[2] 

机构地区：[1]宁夏回族自治区人民医院消化科,银川750021 [2]河北医科大学第四医院内镜科,石家庄050011

出　　处：《肿瘤研究与临床》2018年第2期107-109,共3页Cancer Research and Clinic

摘　　要：目的探讨贲门高级别上皮内瘤变（HGIN）患者血清中血小板因子4（CXCL4）的表达及其临床意义。方法以2010年1月至2011年12月河北医科大学第四医院收治的贲门HGIN患者64例、进展期贲门癌（ACC）患者29例为研究对象，选取同期行内镜筛查的健康人40名为对照组。采用酶联免疫吸附试验（ELISA）检测血清中CXCL4相对表达水平。各组间表达的差异采用方差分析和LSD-t检验进行统计学分析。结果贲门HGIN组CXCL4相对表达量为（0.75±0.37）ng/ml，ACC组为（0.87±0.33）ng/ml，对照组为（1.13±0.51）ng/ml，差异有统计学意义（F=10.77，P〈0.05）；贲门HGIN组、ACC组的相对表达量均低于对照组，差异均有统计学意义（t=4.80、t=2.67，均P〈0.05）；贲门HGIN组的相对表达量与ACC组比较，差异无统计学意义（t=1.27，P〉0.05）。结论贲门HGIN患者血清中CXCL4表达量降低，CXCL4可能与贲门癌的发生及血管生成有关，其可能成为贲门癌早期筛查的重要血清标志物。Objective To investigate the expression of serum platelet factor 4 （CXCL4） in high-grade intraepithelial neoplasia （HGIN） of gastric cardia and its clinical significance. Methods Sixty-four HGIN patients and 29 patients with advanced cardiac cancer （ACC） from January 2010 to December 2011 in the Fourth Hospital of Hebei Medical University were selected as the research objects. Forty healthy people treated with endoscope screening were chosen as the control group. Enzyme linked immunosorbent assay（ELISA） was used to detect the expression of CXCL4 in serum. The expression differences were compared by using variance analysis and LSD-t.Results The CXCL4 detection showed that the expression levels of CXCL4 were （0.75±0.37） ng/ml, （0.87±0.33） ng/ml, （1.13±0.51） ng/ml respectively in HGIN group, ACC group and the control group （F= 10.77, P 〈 0.05）. The CXCL4 expression levels in HGIN and ACC group were lower than that in the control group （t= 4.80, t= 2.67, both P 〈 0.05）. There was no difference between the CXCL4 expression levels in HGIN and ACC group （t= 1.27, P 〉 0.05）.Conclusions The expression level of CXCL4 in HGIN patients with gastric cardia is significantly decreased. CXCL4 may be related with the occurrence and angiogenesis of gastric cardia cancer, which can be considered as an important serum marker for early screening of gastric cardia cancer.

关 键 词：胃肿瘤 贲门 血小板因子4 高级别上皮内瘤变 

分 类 号：R735[医药卫生—肿瘤]