葡萄糖转运蛋白1与胃癌患者临床病理特征及预后关系的Meta分析  

Relationship between expression of glucose transporter 1 and clinicopathological features and prognosis of patients with gastric cancer： a Meta-analysis

作　　者：赵玲琼 刘杰[2] 张献全[1] 罗治彬 

机构地区：[1]重庆医科大学附属第二医院肿瘤科,400010 [2]川北医学院附属医院心内科,四川南充637000 [3]重庆市人民医院肿瘤血液科,400014

出　　处：《肿瘤研究与临床》2018年第2期120-127,共8页Cancer Research and Clinic

摘　　要：目的系统评价葡萄糖转运蛋白1（GLUT-1）在胃癌中的表达及其与患者临床病理特征和预后的关系。方法计算机检索PubMed、Web of Science、EMbase、Cochrane图书馆、万方数据库及中国知网中有关GLUT-1和胃癌关系的文献，检索时限为从各数据库建立至2017年5月15日，按照纳入及排除标准，由2名研究人员独立进行文献筛选、资料提取和质量评价，并计算合并效应值[比值比（OR）或风险比（HR）]及其95%可信区间（95% CI），应用RevMan5.3软件对数据进行Meta分析。结果最终共纳入11篇文献，其中胃癌组1 714例，正常胃黏膜组431例。系统评价结果显示：胃癌组GLUT-1表达高于正常胃黏膜组，差异有统计学意义（OR=24.23，95% CI 11.86-49.51，P〈0.000 01）。GLUT-1蛋白表达与年龄、性别、肿瘤大小和浸润程度无关（均P〉0.05），而与分化程度（OR=0.41，95% CI 0.25-0.67，P=0.000 4）、有无淋巴结转移（OR=5.11，95% CI 2.73-9.56，P〈0.000 1）、TNM分期（OR=0.32，95% CI 0.20-0.51，P〈0.000 01）有关。GLUT-1与胃癌患者总生存（OS）率相关（HR=1.61，95% CI 1.30-1.99，P〈0.000 1）。结论胃癌组织中GLUT-1蛋白表达高于正常胃黏膜组织，与胃癌的分化程度、淋巴结转移、TNM分期相关，且可能与胃癌患者预后不良有关。Objective To investigate the expression of glucose transporters 1 （GLUT-1） in gastric cancer and its relation with clinicopathological characteristics and prognosis.Methods PubMed, Web of Science, EMbase, Cochrane Library, WanFang Databases and China National Knowledge Internet （CNKI） were used to search literatures about GLUT-1 and gastric cancer. From the day of establishment to May 15, 2017, according to the inclusion and exclusion criteria, 2 researchers independently screened studies, extracted data and assessed quality of the included studies. Effect value and 95% CI was calculated respectively. Then Meta-analysis was conducted by using RevMan5.3 software.Results A total of 11 articles were enrolled, including 1 714 cases in the gastric cancer group and 431 cases in the normal gastric mucosa group. The results of Meta-analysis showed that GLUT-1 expression was higher in the gastric cancer group than that in the normal group, and there was a significant difference （OR= 24.23, 95% CI 11.86-49.51, P 〈 0.000 01）. The expression of GLUT-1 was not related with age, gender, tumor size and invasion depth （all P 〉 0.05）, but related with differentiated degree （OR= 0.41, 95% CI 0.25-0.67, P= 0.000 4）, lymphatic metastasis （OR= 5.11, 95% CI 2.73-9.56, P 〈0.000 1）, and TNM staging （OR= 0.32, 95% CI 0.20-0.51, P 〈 0.000 01）. Moreover, GLUT-1 had a correlation with the overall survival rate of gastric cancer （HR= 1.61, 95% CI 1.30-1.99, P 〈 0.000 1）.Conclusions GLUT-1 protein expression is higher in gastric cancer tissues than that in normal gastric mucosa, and it is related to tumor differentiation degree, lymph node metastasis, TNM staging. Besides, GLUT-1 may be correlated with poor prognosis of patients with gastric cancer.

关 键 词：胃肿瘤 单糖转运蛋白质类 META分析 

分 类 号：R735.2[医药卫生—肿瘤]