糖尿病认知功能障碍的机制及中药干预研究进展  

Pathogenesis of diabetic cognitive dysfunction and intervention by traditional Chinese medicine

作　　者：翟亚东 孙桂波[1] 吴咏梅 叶田园[1] 孟祥宝 孙晓波[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所国家中医药管理局中药干预糖脂代谢紊乱性疾病药效评价重点实验室中药(天然产物)创新药物研发北京市重点实验室,北京100193 [2]长春中医药大学药学院,吉林长春130117

出　　处：《中国药理学通报》2018年第3期303-308,共6页Chinese Pharmacological Bulletin

基　　金：国家科技部"重大新药创制"科技重大专项(No20172X09101003-009);协和青年基金资助项目(No3332016076)

摘　　要：糖尿病认知功能障碍(DCD)是糖尿病患者常见的慢性并发症。DCD的发病机制复杂,尚未完全阐明,其中代谢异常、胰岛素抵抗、内质网应激、神经元钙稳态失衡、炎症反应、血脑屏障损伤、线粒体损伤等均参与其中,共同组成了复杂而相互关联的发病机制。近年来,中药在改善DCD方面取得了较大的进展。该文对DCD的发病机制以及中药在治疗和预防DCD的研究进展予以综述。Diabetic cognitive dysfunction（ DCD） is a common chronic complication of diabetes mellitus with sophisticated pathogenesis which has not yet been fully elucidated. In this review paper,the mechanisms of metabolic abnormalities,insulin resistance,endoplasmic reticulum stress,neuronal calcium dyshomeostasis,in ammation,blood brain barrier impairment,and mitochondrial injury associated with DCD are reviewed. In addition,the prevention and treatment of DCD by traditional Chinese medicines（ TCMs） and the effective compounds are comprehensively summarized,in order to provide an updated overview on the DCD pathogenesis,as well as the scientific evidence underpinning the use of TCM interventions for the treatment and prevention of DCD.

关 键 词：糖尿病 认知功能障碍 发病机制 代谢异常 中药 治疗和预防 

分 类 号：R-05[医药卫生] R338.64