牛磺酸镁抗豚鼠离体心脏2型短QT综合征作用的研究  

Investigations on effect of taurine-magnesium coordination compound against SQT2 in isolated hearts of guinea pig

作　　者：孙凯 李燕 安梦瑶 潘莹莹 康毅 尹永强 孙涛 高卫真 娄建石 

机构地区：[1]天津医科大学基础医学院药理学系,天津300070 [2]安徽医科大学附属阜阳医院药剂科,安徽阜阳236000

出　　处：《中国药理学通报》2018年第3期348-352,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81373410);天津市自然科学基金青年项目(No 14JCQNJC13700)

摘　　要：目的观察牛磺酸镁配合物(taurine-magnesium coordination compound,TMCC)对豚鼠离体心脏表面心电图的影响,初步探索TMCC抗2型短QT综合征(type 2 short QT syndrome,SQT2)的作用。方法采用Langendorff主动脉逆行灌流法对豚鼠离体心脏进行灌流,利用Biopac生理记录仪采集豚鼠离体心脏表面Ⅱ导联心电图以观测TMCC在应用吡那地尔(pinacidil)诱导SQT2条件下,对豚鼠离体心脏QT间期、有效不应期、跨室壁复极离散度、RR和QT间期不稳定性等的影响。结果 TMCC能够逆转吡那地尔所致QT间期的缩短,逆转吡那地尔所致有效不应期的缩短,降低吡那地尔所致的跨室壁复极离散度增大,减小吡那地尔所致的RR、QT间期不稳定性增大。结论 TMCC通过延长QT间期和有效不应期、降低跨室壁复极离散度和不稳定性等作用对SQT2有一定治疗作用。Aim To investigate the effect of taurinemagnesium coordination compound（ TMCC） on electrocardiogram of isolated guinea pig hearts,hoping to describe a primary research on its characteristic of antishort QT syndrome. Methods The isolated guinea pig heart was retrograde perfused using Langendorff technique. In order to determine the effects of TMCC on QT interval,transmural dispersion of repolarization,effective refractory period,instability of RR interval and instability of QT interval in the presence of potassium channel opener pinacidil,the electrocardiogram of isolated guinea pig hearts was recorded using Biopac physiological recorder. Results The shortened QT interval and the effective refractory period induced by pinacidil could be prolonged by TMCC; the increased transmural dispersion of repolarization induced by pinacidil could be decreased by TMCC; the increased instability of RR and QT interval induced by pinacidil could be decreased by TMCC. Conclusion TMCC has the effects of anti-SQT2 by prolonging the QT interval and the effective refractory period,reducing the transmural dispersion of repolarization and instability.

关 键 词：牛磺酸镁 短QT综合征 有效不应期 离散度 不稳定性 吡那地尔 

分 类 号：R-332[医药卫生] R322.11