远志、石菖蒲及药对干预AD发病机制的研究概况  

Research Progress on Mechansim of Polygala and Acorus Tatarinowii Schott and Drug Pair of Them Intervening Alzheimer’s Disease

作　　者：张琦 沈杨 贺文彬 

机构地区：[1]山西中医药大学山西省重点实验室脑藏象学山西省高等学校重点实验室,山西太原030619 [2]山西省中医药研究院,山西太原030012

出　　处：《辽宁中医杂志》2018年第1期209-211,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81473375)

摘　　要：近年来,中药及从中提取的有效成分在治疗阿尔茨海默病（Alzheimer＇s disease,AD）方面疗效取得一定进展。通过查阅文献资料,远志的主要有效成分为远志皂苷、远志寡糖酯,石菖蒲的主要有效成分为β-细辛醚,其有效成分都在中枢神经系统中具有相应的药理作用,主要以防治AD、改善学习记忆功能障碍为主。文章将远志、石菖蒲单味药及药对干预AD的不同病理机制进行概述。In recent years,traditional Chinese medicine and the effective components in the treatment of Alzheimer＇s disease have obtained great progess. Through the consult literature material,the main effective components in polygala are tenuigenin and ucrose esters. The main effective components in Acorus tatarinowii Schott is β-asarone and the main effective components of them all have the corresponding pharmacological effects in CNS. The prevention and treatment of AD is Mainly given priority to improve learning and memory dysfunction. This article writes different pathological mechanisms of polygala and Acorus tatarinowii schott single herbs and medicine pairs to intervene the AD.

关 键 词：远志 石菖蒲 阿尔茨海默病 发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]