PINK1/Parkin通路在线粒体自噬氧化损伤中的作用  

The Role of PINK1/Parkin Pathway Mitophagy in Oxidative Damage

作　　者：梁丹阳 戴汉川[1] 

机构地区：[1]华中农业大学动物医学院动物生物化学教研室,武汉430070

出　　处：《中国细胞生物学学报》2018年第1期116-123,共8页Chinese Journal of Cell Biology

基　　金："十三五"国家重点研发计划项目(批准号:2016YFD0501210;2017YFD0502301);中央高校基本科研基金专项(批准号:2011QC004)资助的课题~~

摘　　要：线粒体是细胞进行氧化还原反应的主要场所,其数量、质量和功能的完整性对调节细胞内环境稳态和维持细胞正常生理功能发挥着重要作用。当机体受不利环境影响时,体内产生活性氧类(reactive oxygen species,ROS)和活性氮类(reactive nitrogen species,RNS)的水平显著增加,导致线粒体结构紊乱与功能障碍,引发机体氧化损伤,并且激活PINK1(PTEN induced putative kinase 1)/Parkin信号通路诱导的线粒体自噬,该通路同时也参与了细胞氧化损伤过程。该文从ROS与氧化应激、PINK1/Parkin通路与线粒体自噬及氧化损伤等方面展开,重点概述了PINK1/Parkin通路调控线粒体自噬在氧化损伤中的作用,为抗氧化产品的研发和机体氧化损伤相关疾病的防治提供新的思路与科学依据。Mitochondria is the main place of redox reaction for cells. The quantity, quality and functional integrity of mitochondria play an crucial role in regulating cellular homeostasis and maintaining physiological functions. When body is exposed to the harmful environmental conditions, the level of free radicals such as reactive oxygen species（ROS） and reactive nitrogen species（RNS） increase significantly, which causing serious structure disorder and function obstacle to mitochondria, then aggravating oxidative damage of body, besides activating PINK1/Parkin pathway to induce mitochondrial autophagy. Meanwhile, this pathway also participates in the process of cellular oxidative damage. In this paper, we make a comprehensive overview from the following aspects： ROS and oxidative stress, PINK1/Parkin pathway and mitophagy, cellular mitophagy with oxidative damage and so on, especially focus on the action of PINK1/Parkin pathway regulating mitophagy in oxidative damage. These theories will be expected to provide a new study idea and scientific basis for researching and developing the antioxidant product, as well as researching how to alleviate and prevent oxidative damage related diseases.

关 键 词：ROS 氧化应激 PINK1/Parkin 线粒体自噬 氧化损伤 

分 类 号：Q25[生物学—细胞生物学]