CAS Scientists Visualize the "Annual Rings" in Human Genome  

作　　者：LIU Guanghui XU Tao QU Jing 

机构地区：[1]National Laboratory of Biomacromolecules Institute of Biophysics,Chinese Academy of Sciences [2]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences

出　　处：《Bulletin of the Chinese Academy of Sciences》2017年第4期241-242,共2页中国科学院院刊（英文版）

基　　金：supported by National Basic Research Program of China(973 Program);the Strategic Priority Research Program of CAS;Beijing Natural Science Foundation;National High Technology Research and Development Program of China;National Natural Science Foundation of China;Program of Beijing Municipal Science and Technology Commission;Key Research Program of CAS;the Thousand Young Talents program of China

摘　　要：Aging,the major risk factor for a wide range of chronic diseases,is determined by both genetic and epigenetic factors.Accurate technology to track the chromatin dynamics in live cells is required for understanding the deeper mechanisms of aging process.So far,several technologies,including fluorescent in situ hybridization(FISH),TALE and CRISPR/d Cas9system,have been utilized to image specific loci in human genome.However,they are limited toAging, the major risk factor for a wide range of chronic diseases, is determined by both genetic .and epigenetic factors. Accurate technology to track the chromatin dynamics in live cells is required for understanding the deeper mechanisms of aging process.

关 键 词：CAS 染色体 科学家 戒指 老化过程 风险因素 动力学 染色质 

分 类 号：R394[医药卫生—医学遗传学]