Independent and combined effects of environmental factors and miR-126, miR-143, and miR-145 on the risk of coronary heart disease  

作　　者：Da-Cen LIN Jia-Bing LIN Zhou CHEN Rong CHEN Chun-Yu WAN Shao-Wei LIN Qi-Shuang RUAN Huang-Yuan LI Si-Ying WU 

机构地区：[1]Department of Epidemiology and Health Statistics, the Key Laboratory of Environment and Health among Universities and Colleges in Fujian, School ofPublic Health, Fujian Medical University, Minhou County, Fuzhou, Fujian, China [2]Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fujian, China [3]Fujian Medical University Union Hospital, Fujian, China [4]Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China

出　　处：《Journal of Geriatric Cardiology》2017年第11期688-695,共8页老年心脏病学杂志（英文版）

摘　　要：Objective To evaluate the effects of environmental factors and microRNAs （miRNAs） （miR-126, miR-143, and miR-145） on the risk of coronary heart disease （CHD）. Methods A frequency-matched case-control study （450 patients, 450 controls） was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, rniR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction （PCR） in pe- ripheral blood mononuclear cells. Unconditional logistic regression models were used for statistical evaluation. Results Alcohol consumption, high-salt diets, high-intensity work, and lack of physical activity were significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. MiR-126, miR-143, and miR-145 were highly expressed in the CHD group compared with the control group. After adjustment for other environmental factors, unconditional logistic regression results revealed that miR-126, miR-143, and depression were the independent risk factors of CHD, and light diet was the independent protective factor of CHD. Conclusions Our data suggest that a family history of CHD, anxiety, and alcohol consumption was significantly associated with increased CHD risk, whereas light diet was significantly associated with decreased risk. Furthermore, miR-126 and miR-143 in combination with several risk factors, could play a joint role in the development of CHD. Therefore, it is necessary to manage patients with CHD in all directions and multiple level.

关 键 词：Case-control study Coronary heart disease Environmental factors Gene-environment interaction MiR- 126 MiR- 143 MiR- 145 

分 类 号：TS262.5[轻工技术与工程—发酵工程] X322[轻工技术与工程—食品科学与工程]