非糜烂性反流病患者生活质量评价  

Quality of life in patients with non-erosive reflux diseases

作　　者：王轶[1] 朱生樑[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院消化科,上海200437

出　　处：《广东医学》2018年第3期438-442,共5页Guangdong Medical Journal

基　　金：上海市科委科技支撑项目(编号:13401902800)

摘　　要：目的从躯体生理功能、心理情绪状况、社会活动等多个维度全面评估非糜烂性反流病(NERD)患者的生活质量,探寻影响患者生活质量的关键因素。方法纳入100例NERD患者,填写临床症状量表、医院焦虑抑郁量表(HADS)、胃食管反流病生存质量量表(GERD-HRQL)和胃肠道生活质量指数量表(GIQLI),通过量表得分对量表内各维度之间及各量表之间的关系进行分析。结果 (1)NERD患者HADSD高于HADS-A积分,两者相关系数r=0.54。(2)GIQLI中除心理情绪与特殊疾病状况之间无直线相关关系外,自觉症状、躯体生理功能、心理情绪状况、社会活动和特殊疾病状况两两间均呈正相关;自觉症状、躯体生理功能、心理情绪状况、社会活动、特殊疾病状况与GIQLI总积分的相关系数分别为0.740、0.795、0.823、0.733、0.549。(3)临床症状积分与HAD-A积分、HAD-D积分、GERD-HRQL积分间存在直线相关性,相关系数依次为0.385、0.273、0.421。(4)GIQLI总积分与临床症状、HAD-A、HAD-D、GERD-HRQL积分的相关系数依次为-0.668、-0.586、-0.444、-0.255,均呈负相关。结论 GIQLI量表能够全面、客观地评价NERD患者的生活质量,与症状积分量表、HADS量表相关性良好。心理情绪状况是影响NERD患者自觉症状、躯体生理功能、社会活动及总体生活质量的关键因素。Objective To comprehensively evaluate the quality of life of patients with non - erosive reflux disea- ses （NERD） from aspects of physiology, psychology and social activities; and to explore the key factors that affect the quality of life. Methods We recruited 100 patients with NERD. They were asked to fill in Clinical Symptom Scale, Hospital Anxiety and Depression Scale （HADS） , Health Related Quality of Life Scale for Castro - esophageal Reflux Dis- ease （ GERD - HRQL） and Gastrointestinal Quality of Life Index （GIQLI）. Statistical analysis on the correlations within and between scales was conducted. Results The HADS - D score was higher than the HADS - A score, as the correla- tion coefficient between them was 0. 54. There was no correlation between psychological emotion and special disease condi- tions. There were positive correlations among subjective symptoms, body physiological function, emotional status, social activities and special disease conditions in GIQLI. The con＇elation coefficients between subjective symptoms, body physio- logical function, emotional status, social activities or special disease conditions and total score of CIQL] were 0. 740, 0. 795, 0. 823, 0. 733 or 0. 549, respectively. There were linear correlations between clinical symptom score and HAD - A, HAD- D or GERD- HRQL score, with the correlation coefficients were 0. 385, 0. 273 or 0. 421, respectively. The correlation coefficients between the overall GIQLI score and clinical symptoms, HAD - A, HAD - D or GERD - HRQL score were - 0. 668, - 0. 586, - 0. 444 or - 0. 255, respectively. Conclusion GIQLI scale can comprehensively and objectively reflect the living quality of patients with NERD, and is closely related to symptom score scale and HADS scale. Psychological and emotional status are the key factors affecting NERD patients＇ subjective symptoms, body physiological function, social activities and overall quality of life.

关 键 词：非糜烂性反流病 生活质量 胃肠道生活质量指数 医院焦虑抑郁量表 胃食管反流病生存质量量表 

分 类 号：R571[医药卫生—消化系统]