复方阿胶浆对化疗所致小细胞肺癌骨髓抑制的影响  

Efficacy of compound e-jiao slurry on marrow suppression of small-cell lung cancer after chemotherapy

作　　者：周勇[1] 侯华英[1] 徐英[1] 姜玉华[1] 

机构地区：[1]山东大学第二医院肿瘤防治中心,山东济南250033

出　　处：《山东大学学报（医学版）》2018年第2期14-17,共4页Journal of Shandong University:Health Sciences

基　　金：山东省自然科学基金(ZR2017MH027)

摘　　要：目的观察复方阿胶浆对化疗所致小细胞肺癌患者骨髓抑制的影响。方法将确诊的135例小细胞肺癌患者分为对照组(n=70)和治疗组(n=65),对照组给予EP方案常规化疗,治疗组在EP方案常规化疗同时口服复方阿胶浆,3次/d,20 m L/次;观察两组患者化疗完成情况及化疗后的血红蛋白(Hb)、血小板(PLT)、白细胞(WBC)和中性粒细胞(NEUT)变化等骨髓抑制情况。结果治疗组的化疗完成率高于对照组;治疗组的WBC、NEUT下降幅度明显低于对照组(P<0.05)。结论复方阿胶浆可降低WBC及NEUT骨髓抑制发生率,并改善化疗所致小细胞肺癌患者的WBC及NEUT减少情况。Objective To observe the efficacy of compound e-jiao slurry on chemotherapy-resulted marrowsuppression of small-cell lung cancer. Methods A total of 135 patients with small-cell lung cancer were divided into the control group（ n =70） and treatment group（ n = 65）. The control group was treated with EP chemotherapy program,while the treatment group took the compound e-jiao slurry（ 20 m L every time and three times every day） companying with EP chemotherapy program.The chemotherapy completion rates of patients were calculated. The marrowsuppression,especially the change of hemoglobin,platelet,white blood cell（ WBC） and neutrophil（ NEUT） counts were observed. Results The chemotherapy completion rate of the treatment group is higher than that of the control group. The decreasing values of WBC and NEUT counts in these two groups were statistically significant（ P〈0.05）. Conclusion Compound e-jiao slurry decreases the incidence rate of the chemotherapy-resulted marrowsuppression（ WBC,NEUT） and relieves the decrease of WBC and NEUT counts.

关 键 词：复方阿胶浆 小细胞肺癌 化疗 骨髓抑制 

分 类 号：R730.5[医药卫生—肿瘤]