不同抗菌药物治疗肝硬化上消化道出血感染患者的临床分析  

Clinical Analysis of Different Antimicrobial Agents in the Treatment of Cirrhosis Patients with Upper Gastrointestinal Bleeding and Infections

作　　者：何龙芳[1] 

机构地区：[1]广东省信宜市人民医院,广东茂名525300

出　　处：《哈尔滨医药》2017年第6期516-517,共2页Harbin Medical Journal

摘　　要：目的探讨不同抗菌药物在治疗肝硬化上消化道出血合并感染患者的临床疗效。方法选取肝硬化上消化道出血感染患者117例,收治时间为2015年9月至2016年12月,随机分成A、B、C三组,每组各39例,其中A组采用硫酸依替米星治疗、B组采用头孢曲松钠治疗、C组采用亚胺培南西司他丁治疗。比较三组患者的细菌清除率、感染控制效率及并发症的发生情况。结果 A组患者细菌清除率高达94.29%,总有效率为94.87%,并发症发生率为2.56%;B组患者细菌清除率为84.38%,总有效率为84.62%,并发症发生率为5.13%%;C组患者细菌清除率为81.82%,总有效率为82.05%,并发症发生率为5.13%%。A组分别与B、C组比较,在细菌清除率、总有效率及并发症发生率上差异均有统计学意义(P<0.05);B组与C组比较,在细菌清除率、总有效率及并发症发生率上差异均无统计学意义(P>0.05)。结论硫酸依替米星在肝硬化上消化道出血并发感染的治疗上疗效明显优于头孢曲松钠和亚胺培南西司他丁,能够有效改善患者的临床症状。Objective To investigate the clinical efficacy of different antimicrobial agents in the treatment of cirrhosis with upper gastrointestinal bleeding and infections.Methods Selected 117 cases of cirrhosis patients with upper gastrointestinal bleeding and infections in our hospital,treated time was from September 2015 to December 2016,randomly divided into groups A,B and C,each group of 39 cases.Group A was treated with etimicin sulfate,group B was treated with ceftriaxone sodium and group C was treated with imipenem.The bacterial clearance rate,infection control efficiency and complications were compared between the three groups.Results In group A,the bacterial clearance rate was 94.29%,the total effective rate was 94.87% and the complication rate was 2.56%,in group B,the bacterial clearance rate was 84.38%,the total effective rate was 84.62% and the complication rate was 5.13%,ingroup C,the bacterial clearance rate was 81.82%,the total effective rate was 82.05% and the complication rate was 5.13%.Group A compared with group B and C,the difference of bacterial clearance rate,total effective rate and complication rate were statistically significant（P〈0.05）,and there was no significant difference in the bacterial clearance rate,total effective rate and complication rate between group B and group C（P 〉0.05）.Conclusion The efficacy of etimicin sulfate in cirrhosis patients with upper gastrointestinal bleeding and infections is superior to ceftriaxone sodium and imipenem,which can effectively improve the clinical symptoms of patients.

关 键 词：肝硬化 抗菌药物 上消化道出血 感染 

分 类 号：R575.2[医药卫生—消化系统]