早期肠内免疫微生态营养联合低氮肠外营养对治疗重症急性胰腺炎免疫、炎症及机体预后的影响  

The Effect of Early Enteral Immunization With Parenteral Nutrition and Enteral Nutrition in the Treatment of Severe Acute Pancreatitis

作　　者：章莉 

机构地区：[1]四川省大竹县人民医院营养科,四川大竹635150

出　　处：《哈尔滨医药》2017年第6期524-525,528,共3页Harbin Medical Journal

摘　　要：目的分析早期肠内免疫营养联合低氮肠外营养对治疗重症急性胰腺炎免疫、炎症及机体预后的影响。方法选择2014年1月至2016年12月,医院重症医学科收治重症胰腺炎患者96例,随机分为对照组和观察组各48例。对照组采用早期常规肠内营养及肠外营养。观察组给予早期肠内免疫微生态营养和低氮肠外营养支持。对比两组治疗前、治疗1周后及2周后免疫、炎症,对比2周后预后指标,观察治疗中不良反应发生情况。结果治疗1、2周后,观察组与对照组外周淋巴细胞计数、CD4+/CD8+水平优于治疗前,组间对比观察组优于对照组,差异有统计学意义(P<0.05)。治疗1周后及2周后,组内对比,观察组与对照组IL-6、IL-2、CRP水平优于治疗前,组间对比观察组优于对照组,差异有统计学意义(P<0.05)。治疗2周后观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。两组均未见不良反应。结论早期肠内免疫微生态营养联合低氮肠外营养治疗重症急性胰腺炎,有助于改善免疫、控制炎症,改善患者预后。Objective To analyze the early enteral nutrition combined with hypocaloric parenteral nutrition on immune treatment of severe acute pancreatitis,inflammatory effects and body prognosis.Methods From January 2014 to December 2016,96 cases of hospital ICU patients with severe acute pancreatitis treated by random number method,the expression of group,control group,the observation group group of 48 cases.The control group received early enteral nutrition and parenteral nutrition.The observation group was given early enteral immune micro ecological nutrition and low nitrogen parenteral nutrition support.Compared two groups of patients before treatment,1 weeks and 2 weeks after immunization,inflammation,compared to 2 weeks after the prognosis,the incidence of adverse reaction was observed during the treatment.Results After 1,2 weeks treatment,the observation group and the control group of the peripheral lymphocyte count,CD4＋/CD8＋ is better than the level before the treatment,the comparison between the two groups than the control group,the difference was statistically significant（P〈0.05）.After 1 weeks of treatment and after 2 weeks.Within group comparison,observation group and control group IL-6,IL-2,CRP levels than before treatment,the comparison between the two groups than the control group,the difference was statistically significant（P〈0.05）.After 2 weeks of treatment,the observation group complication rate was lower than the control group,the difference was statistically significant（P〈0.05 There was no adverse reaction in the two groups.Conclusion Early enteral immunization with micro ecological nutrition combined with low nitrogen and low calorie parenteral nutrition in the treatment of severe acute pancreatitis,help to improve immunity,control inflammation,improve the prognosis of patients

关 键 词：重症胰腺炎 营养支持 肠内免疫营养支持 低氮肠外营养支持 

分 类 号：R576[医药卫生—消化系统]