Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor  

作　　者：Yan Zheng Yu-Qing Rao Jia-Kai Li Yue Huang Peiquan Zhao Jing Li 

机构地区：[1]Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine [2]Department of Ophthalmology, Xinhua Hospital, Chong Ming Branch, Shanghai Jiao Tong University School of Medicine

出　　处：《International Journal of Ophthalmology(English edition)》2018年第2期196-200,共5页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81570829;No.81470642)

摘　　要：AIM： To reveal age-related aqueous cytokine changes in human aqueous humor.METHODS： Aqueous humor was collected from 12 young children（3-6.5 years old） and 71 healthy adults（22-106 years old） with cataract but without other systemic or ocular disorders. Levels of 22 cytokines, chemokines and vascular endothelial growth factor（VEGF） were measured and analyzed.RESULTS： The following proteins showed significant increase from childhood to adult： interferon-gamma（IFN-γ）, interleukin（IL）-13, IL-6, IL-12（p70）, IL-10, CCL2, CCL3, CCL4, CXCL8, CXCL9, CXCL10, IFN-α2 and VEGF（all P〈0.05）. IFN-γ, IL-13, IL-12（p70）, IL-10, CCL3, CXCL9 and VEGF also showed moderate strength age-related increase in the adult group（r〉0.5）. The strength of correlation between aging and CCL4 were fair（r=0.398）. The concentrations of IL-2, IL-4, IL-5, IL-1β and TNF-α were low in both groups.CONCLUSION： From childhood to adult, the immunological milieu of the anterior chamber become more pro-inflammatory and pro-angiogenic. Such changes may represent the parainflammation state of the human eye.AIM： To reveal age-related aqueous cytokine changes in human aqueous humor.METHODS： Aqueous humor was collected from 12 young children（3-6.5 years old） and 71 healthy adults（22-106 years old） with cataract but without other systemic or ocular disorders. Levels of 22 cytokines, chemokines and vascular endothelial growth factor（VEGF） were measured and analyzed.RESULTS： The following proteins showed significant increase from childhood to adult： interferon-gamma（IFN-γ）, interleukin（IL）-13, IL-6, IL-12（p70）, IL-10, CCL2, CCL3, CCL4, CXCL8, CXCL9, CXCL10, IFN-α2 and VEGF（all P〈0.05）. IFN-γ, IL-13, IL-12（p70）, IL-10, CCL3, CXCL9 and VEGF also showed moderate strength age-related increase in the adult group（r〉0.5）. The strength of correlation between aging and CCL4 were fair（r=0.398）. The concentrations of IL-2, IL-4, IL-5, IL-1β and TNF-α were low in both groups.CONCLUSION： From childhood to adult, the immunological milieu of the anterior chamber become more pro-inflammatory and pro-angiogenic. Such changes may represent the parainflammation state of the human eye.

关 键 词：aqueous humor cytokines aging parainflammation macrophage vascular endothelial growth factor 

分 类 号：R77[医药卫生—眼科]