杏芎氯化钠注射液治疗急性脑梗死临床观察  

Clinical observation of Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection on patients with acute cerebral infarction

作　　者：江铮 张龙滨 

机构地区：[1]福州市第二医院神经内科,福建福州350007

出　　处：《中国实用神经疾病杂志》2018年第1期44-46,共3页Chinese Journal of Practical Nervous Diseases

基　　金：福州市科技计划项目(2015-S141-15)

摘　　要：目的研究杏芎氯化钠注射液治疗急性脑梗死患者炎症因子、氧化应激反应及脑血流灌注的影响。方法抽取2015-06—2016-06福州市第二医院收治190例急性脑梗死病例,按照用药不同分为对照组(n=95)与观察组(n=95),对照组实施常规疗法,观察组在对照组基础上予以杏芎氯化钠注射液治疗,对比2组炎症因子水平、氧化应激反应及脑血流灌注相关指标。结果治疗后,观察组MMP-9、SOD、CBF、CBV明显高于对照组,而hs-CRP、TNF?α、MDA、MTT、TTP明显低于对照组(P<0.05)。结论杏芎氯化钠注射液治疗急性脑梗死,可有效降低血清炎症因子水平,改善氧化应激反应及脑血流灌注情况。Objective To investigate the influence of Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection on inflammatory factor,oxidative stress response and cerebral blood perfusion in patients with acute cerebral infarction.Methods Totally 190 cases with acute cerebral infarction in our hospital from June 2015 to June 2016 were selected and divided into the control group（n=95）and the observation group（n=95）.The control group was given routine treatment,the observation group was given Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection.The inflammatory factor level,oxidative stress response and cerebral blood perfusion related indexes of the two groups were compared.Results After treatment,MMP-9,SOD,CBF,CBV of the observation group were significantly higher than those in the control group;hs-CRP,TNF？α,MDA,MTT,TTP were significantly lower than those in the control group（P 0.05）.Conclusion The application of Floium Ginkgo extract and Tertram Ethypyrazine sodium chloride injection can decrease inflammatory factor level,improve oxidative stress response and cerebral blood perfusion condition in the treatment of patients with acute cerebral infarction,it is of higher clinic promotion value.

关 键 词：杏芎氯化钠注射液 急性脑梗死 炎症因子 氧化应激反应 脑血灌注 

分 类 号：R743.33[医药卫生—神经病学与精神病学]