影响中青年急性缺血性卒中脑血管狭窄的危险因素研究  

The Risk Factors for Acute Ischemic Stroke in Young and Middle-aged Patients with CerebroVascular Stenosis

作　　者：葛晓敏 杜磊[1] 马建华[1] 

机构地区：[1]新疆医科大学第一附属医院神经内科,乌鲁木齐830054

出　　处：《神经损伤与功能重建》2018年第2期62-65,共4页Neural Injury and Functional Reconstruction

基　　金：国家自然科学基金(No.81060097)

摘　　要：目的:探讨影响中青年急性缺血性卒中脑血管狭窄的危险因素。方法:回顾性收集中青年急性缺血性卒中临床资料130例,根据检查结果分为血管狭窄组64例和无血管狭窄组66例,并根据血管狭窄程度进一步分为轻度狭窄亚组16例,中重度狭窄亚组17例,闭塞亚组31例。收集甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、TC/HDL-C、TG/HDL-C、LDL-C/HDL-C、高血压史、血糖病史、体质指数(BMI)等资料,分析血脂变量与血管狭窄程度的关系及血管狭窄的危险因素。结果:2组间高血压病史≥10年、TC、TC/HDL-C比较有统计学差异(P<0.05);TC、TC/HDL-C与血管狭窄程度呈正相关(P<0.01);轻度、中重度狭窄亚组TC、TC/HDL-C低于闭塞亚组(P<0.05);高血压病史≥10年、TC/HDL-C可能是新疆中青年急性缺血性卒中血管狭窄的独立危险因素(P<0.05)。结论:TC、TC/HDL-C与中青年急性缺血性卒中血管狭窄水平密切相关;血清TC/HDL-C和高血压病史≥10年可能可作为预测独立中青年急性缺血性卒中血管狭窄的危险因素。Objective： To study the risk factors for acute ischemic stroke m middle-ageo and young patients with cerebrovascular stenosis in Xinjiang. Methods： Clinical data of 130 middle-aged and young patients with acute isehemic stroke were collected. Cases were divided into the cerebrovascular stenosis group （n=64） and the no cerebrovascular stenosis group （n=66）. Stenosis group was further divided into mild stenosis group （n=16）, moderately severe stenosis group （n=17）, and occlusion group （n=31）. Data was collected on patient serum levels of triglyceride （TG）, low-density Lipoprotein cholesterol （LDL-C）, total cholesterol （TC）, high density lipoproteir- cholesterol （HDL-C）, TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, as well as history of high blood pressure, history of diabetes, and BMI. Data was analyzed for correlation between serum lipid index and degree of cerebrovascular stenosis, and analysis of risk factors for cerebrovascular stenosis was performed. Results： Hypertension of 10 years, TC, and TC/HDL-C were significantly different between the cerebrovascular stenosis group and no cerebrovascular stenosis group （P〈0.05）. TC and TC/HDL-C were positively correlated with cerebrovascular ste- nosis degree （P〈0.01）. Serum TC level and TC/HDL-C were significantly lower in the moderate and mild steno- sis groups than in the occlusion group （P〈0.05）. Hypertension of ≥ 10 years and TC/HDL-C were independent risk factors for middle-aged and young patients of ischemic stroke with cerebrovascular stenosis （P〈0.05）. Conclusion： Serum TC and TC/HDL-C were closely related with degree of cerebrovascular stenosis in middle-aged and young patients of acute ischemic stroke in Xinjiang. Hypertension of ≥ 10 years and TC/HDL-C can thus be considered risk factors for middle-aged and young acute ischemic stroke with cerebrovascular stenosis.

关 键 词：中青年 缺血性卒中 头颈CT血管成像 数字减影血管造影 危险因素 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]