榄香烯注射液联合莲芪胶囊治疗中晚期原发性肝癌的临床疗效及对患者血清生长因子的影响  

Clinical study on Lianqi capsule combined with Elemene injection on patients with middle-late primary liver cancer and its effects on serum growth factor

作　　者：王明龙[1] 钱义红 钱春红 张海青[1] 杨雯 蒋寒[1] 

机构地区：[1]湖北省潜江市中心医院放射科,湖北潜江433199 [2]湖北省潜江市中心医院急诊科,湖北潜江433199 [3]湖北省潜江市中心医院康复科,湖北潜江433199

出　　处：《河北中医》2018年第2期234-240,共7页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察榄香烯注射液联合莲芪胶囊治疗中晚期原发性肝癌(PLC)的临床疗效及对患者血清血管内皮生长因子(VEGF)、胰岛素样生长因子2(IGF-2)、胰岛素样生长因子结合蛋白2(IGFBP-2)的影响。方法将60例中晚期PLC患者随机分为2组。对照组30例予经导管肝动脉化疗栓塞术(TACE)治疗,每3周治疗1次为1个疗程,治疗2个疗程;治疗组30例在对照组治疗基础上加用榄香烯注射液联合莲芪胶囊治疗。榄香烯注射液2周为1个疗程,休息1周后进行下1个疗程,治疗2个疗程;莲芪胶囊介入前1周连续口服7 d。比较2组临床疗效;观察2组治疗前后肝功能指标[白蛋白(Alb)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]变化;观察2组治疗前后中医证候积分变化;比较2组中医证候疗效;观察2组治疗前后卡氏评分(KPS)变化;比较2组功能状态疗效;观察2组治疗前后血常规白细胞计数(WBC)、血小板计数(PLT)、血红蛋白(Hgb)及肾功能指标血尿素氮(BUN)、血肌酐(Cr)变化;观察2组治疗前后VEGF、IGF-2、IGFBP-2水平变化。结果治疗组总有效率26.67%,控制率96.67%,对照组总有效率10.00%,控制率80.00%,2组总有效率、控制率比较差异均有统计学意义(P<0.05),治疗组临床疗效优于对照组。治疗组治疗后Alb较本组治疗前升高(P<0.05),ALT、AST均较本组治疗前降低(P<0.05);对照组治疗后ALT、AST均较本组治疗前降低(P<0.05)。治疗后治疗组Alb高于对照组(P<0.05),ALT、AST均低于对照组(P<0.05)。2组治疗后中医证候积分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。治疗组改善率73.33%,对照组改善率46.67%,2组改善率比较差异有统计学意义(P<0.05),治疗组中医证候疗效优于对照组。2组治疗后KPS评分均较本组治疗前升高(P<0.05),治疗后治疗组高于对照组(P<0.05)。治疗组功能状态改善率46.67%,对照组功能状态改善率20.00%,2组改善率比较差异有统�Objective To observe the clinical study on Lianqi capsule combined with Elemene injection on patients with middle-late primary liver cancer(PLC) and its effects on serum vascular endothelial growth factor(VEGF),insulin-like growth factor-2(IGF-II) and insulin-like growth factor binding protein-2(IGFBP-2).Methods 60 patients with middle-late PLC were randomly divided into two groups.30 cases in control group were treated by transcatheter arterial chemoembolization(TACE),One course of treatment was treated once even three weeks continuously treated for two conrses.30 cases in treatment group were treated by Lianqi capsule combined with Elemene injection on the basis of the control group.The Elemene injectal was on course for two weeks.After on week of rest.The next course of treatmenf was carried out continuously treated for two conrses.The liver indexes including albumin(Alb),alanine aminotransferase(ALT) and aspartate aminotransferase(AST) before and after treatment were observed in two groups.The score changes of TCM syndrome were observed and the curative effects of TCM syndrome were compared in two groups.The changes of KPS score before and after treatment were observed in two groups.The effects of functional status were compared between two groups.The changes of blood routine including white blood cell(WBC),platelets(PLT) and hemoglobin(Hgb),and the renal function indexes including blood urea nitrogen(BUN) and serum creatinine(Cr),and level changes of VEGF,IGF-Ⅱ,IGFBP-2 before and after treatment were observed in two groups.Results There were statistical differences on the total effective rate and the control rate of between the treatment group(26.67%,96.67%) and the control group(10.00%,80.00%,P < 0.05),and the clinical effects in treatment group was superior to that in control group.The Alb after treatment was increased in treatment group(P < 0.05),ALT and AST were decreased(P < 0.05),and ALT and AST reduced(P <0.05).The ALT and AST after treatment were reduced in control group(P < 0.05).After treatment,A

关 键 词：肝肿瘤 中西医结合疗法 内皮生长因子 

分 类 号：R735.705.3[医药卫生—肿瘤]