丹参川芎嗪注射液对比丹参多酚酸盐注射液治疗冠心病心绞痛的药物经济学评价  

Cost-effectiveness analysis of Danshenchuanxiongqin injection vs salvianolate injection for angina pectoris

作　　者：冯双[1] 胡明[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《药学实践杂志》2018年第2期147-155,共9页Journal of Pharmaceutical Practice

摘　　要：目的评价丹参川芎嗪注射液与丹参多酚酸盐注射液治疗冠心病心绞痛的临床疗效及经济性。方法检索CBM、中国知网、维普、万方、Cochrane library、Pubmed、Embase等中英文数据库,查找丹参川芎嗪和丹参多酚酸盐治疗冠心病心绞痛的随机对照临床试验,按照纳入与排除标准筛选文献,提取资料,以间接荟萃(Meta)分析的方法系统评价两种药物治疗冠心病心绞痛的临床疗效;经济学评价采用成本效果法进行,其中成本指直接成本,包括常规治疗费、给药费、检查费以及住院费。结果间接Meta分析结果显示,丹参川芎嗪与丹参多酚酸盐治疗冠心病心绞痛的有效率分别为89.51%和92.52%,心电图改善率分别为81.40%和84.05%。治疗心绞痛的疗程费用分别为4 099.71元和5 410.16元;丹参川芎嗪与丹参多酚酸盐的心绞痛改善成本效果比分别为45.80和58.48,心电图改善的成本效果比分别为50.36和64.37,敏感性分析结果稳定。结论与丹参多酚酸盐注射液相比,在治疗冠心病心绞痛方面,丹参川芎嗪注射液可能更具经济学优势。Objective To compare the cost-effectiveness of Danshenchuanxiongqin injection versus salvianolate injection for angina pectoris.Methods Databases including CBM,CNKI,VIP,Cochrane library,Pubmed,Embase and Wanfang were electronically searched for the randomized controlled trials(RCTs)on the comparison between Danshen Chuanxiongqin injection and Dsnshenduofensuanyan injection.Literatures were screened and data were extracted in accordance with the inclusion and exclusion criteria.Clinical efficacy of the two drugs were obtained through indirect Meta-analysis.Economic evaluation was carried out using the cost-effectiveness analysis,direct medical cost data included the cost of conventional treatment,drug,examination and hospital expenses.Results Through indirect Meta-analysis,the improvement efficiency of angina were 89.51%and 92.52% for Danshenchuanxiongqin injection and salvianolate injection.The success rates of ECG were 81.40% and84.05% for two drugs. The costs of Danshenchuanxiognqin injection and salvianolate injection were 4 099.71 and5 410.16 CNY.The Cost-effectiveness ratio of angina improve of two drugs were 45.80 and 58.48,while the ECG improve were 50.36 and 64.37.And the sensitivity analysis results were stable.Conclusion Compared to salvianolate injection,salvianolate injection was probably cost-effective for angina pectoris.

关 键 词：丹参川芎嗪 丹参多酚酸盐 冠心病心绞痛 间接Meta分析 成本效果分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]