IL-1β表达与食管鳞状细胞癌患者临床病理参数关系的分析  

Correlation of IL-1β expression with clinicopathological parameters in esophageal squamous cell carcinoma

作　　者：周剑 冯晨 郑树涛[2] 刘清[2] 刘涛[2] 谭豆豆 马蓉 陈玉梅[1] 卢晓梅 

机构地区：[1]新疆医科大学附属肿瘤医院,乌鲁木齐830011 [2]新疆医科大学临床医学研究院,乌鲁木齐830011 [3]乌鲁木齐市友谊医院病理科,乌鲁木齐830000

出　　处：《新疆医科大学学报》2018年第3期271-273,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(U1603284,U1303321);新疆维吾尔自治区重大科技专项计划(201430123-1);新疆重大疾病重点实验室开放课题(SKLIB-XJMDR-2016)

摘　　要：目的探讨白细胞介素1-β(IL-1β)在食管鳞状细胞癌(ESCC)中的表达和患者预后及临床病理参数的相关性。方法应用免疫组织化学Envision二步法检测IL-1β在ESCC组织及癌旁组织中的表达。结果食管癌组织IL-1β阳性表达的细胞明显多于癌旁组织(P<0.05)。IL-1β阳性表达与肿瘤淋巴结转移及T分期明显相关(P<0.05);与性别、年龄和临床分级无明显相关性(P>0.05)。生存分析结果显示,IL-1β阳性表达与患者预后明显相关(P<0.05)。结论 IL-1β阳性表达与ESCC淋巴结转移及T分期有关,且影响患者预后,提示IL-1β表达可能作为判断ESCC预后的指标。Objective To investigate the correlation between the expression of IL-1βin esophageal squamous cell carcinoma(ESCC)and prognosis and clinicopathological parameters.Methods The expression of IL-1βin ESCC and adjacent carcinoma tissue(ACT)was detected by immunohistochemistry.ResultsThe expression rates of IL-1βwere significantly higher than those in the ACT group(P <0.01).The expression of IL-1βsignificantly associated with lymph node metastasis and T classification(P <0.05).We did not find the correlations between IL-1βexpression and age,gender and clinical stage(P >0.05).The survival curve analysis revealed that IL-1βexpression significantly associated with prognosis(P <0.05).Conclusion The expression of IL-1βin esophageal cancer tissues had significant correlation with lymph node metastasis,T classification and prognosis,which suggested that IL-1βmight be used as a potential prognostic marker in ESCC.

关 键 词：白细胞介素1-β(IL-1β) 食管癌 组织芯片 

分 类 号：R735.1[医药卫生—肿瘤]