阿司匹林-LDHs-壳聚糖微球的制备及其体外释放研究  

Preparation and in vitro releasing property of aspirin-LDHs-chitosan microspheres

作　　者：王启平 李慧 王慧云[2] 孙珊珊[2] 丁林[2] 张波[2] 全先高[2] 

机构地区：[1]济宁市任城区卫生监督所,济宁272000 [2]济宁医学院药学院,日照276826

出　　处：《济宁医学院学报》2018年第1期59-63,68,共6页Journal of Jining Medical University

基　　金：济宁医学院科研项目(JY2013KJ022);济宁医学院教师科研扶持基金(JY2017KJ048)

摘　　要：目的制备阿司匹林-LDHs-壳聚糖微球,并研究其体外释放性能。方法以硝酸锌、硝酸铝和壳聚糖为原料,以阿司匹林为模型药物,采用乳化交联法制备阿司匹林-LDHs-壳聚糖微球,应用傅立叶红外变换光谱仪(FT-IR)、马尔文激光粒度仪、紫外可见分光光度计(UV-spectrophotometer)、电光显微镜表征载药微球的结构、性能及形态;以载药量和包封率为评价指标,考察了阿司匹林用量、LDHs-壳聚糖用量,阿司匹林/明胶,戊二醛用量等影响因素对载药微球的影响;通过体外释放实验探讨了载药微球在不同模拟释放液中的释药规律。结果在3%阿司匹林用量、0.03g Cs-LDHs、阿司匹林/明胶1∶8、戊二醛0.5ml制备的微球有最佳包封率和载药量。最优工艺制得的载药微球平均粒径为2793nm。结论所得微球粒径分布较均匀,球形度好;该微球更倾向于在pH较高的盐酸溶液中释放。Objective To prepare the aspirin – LDHs-chitosan Microspheres,and study its in vitro release properties.Methods The aspirin-LDHs-chitosan Microspheres were prepared with zinc nitrate,aluminiumnitrate and chitosan as raw material,aspirin as the model drug. The microspheres are characterized by Fourier transform infrared spectrometer（FTIR）,Malvern laser particle size analyzer,UV-spectrophotometer（UV）,as well as Electric microscope. The influence of dosage of aspirin,amount of Cs-LDHs,ratio of aspirin/gelatin and dosage of crosslinking agent on the drug-loaded and entrapment rate of microspheres were explored. And in vitro release experiments were used to study the drug release properties of the microsphere. Results Results showed that the average particle size was 2793 nm under the optimal conditions of the dosage of aspirin 3%,the amount of Cs-LDHs 0. 03 g,the ratio of aspirin/gelatin 1∶ 8,and the dosage of crosslinking agent 0. 5 ml respectively. Conclusion The shape and size of microspheres are uniform. aspirin – LDHs-Cs Microspheres is pH-sensitive and tends to show a larger release percentage in the phosphate buffer solution solution.

关 键 词：双层氢氧化物 阿司匹林 微球 缓释 

分 类 号：TB332[一般工业技术—材料科学与工程]