配偶双方感染幽门螺杆菌采用益生菌联合三联疗法进行同时治疗与单方治疗疗效对比研究  

Comparative study of probiotics combined with triple therapy in the treatment of Helicobacter pylori infection in both spouses

作　　者：赵文涛 林苗 焦小红 曹高峰 

机构地区：[1]核工业第四一七医院内二科,陕西西安710600 [2]核工业第四一七医院内三科,陕西西安710600

出　　处：《临床军医杂志》2018年第2期191-193,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨配偶双方感染幽门螺杆菌(Hp)采用益生菌联合三联疗法进行同时治疗与单方治疗的疗效及对患者血清炎症因子水平的影响。方法选择自2016年1月至2017年1月核工业417医院收治的Hp感染且其配偶也均确认为Hp感染的患者86例为研究对象。将所有符合标准的患者根据患者自身及其配偶的意愿,分成仅患者本人治疗,其配偶不治疗组(A组,n=43)和患者本人与配偶共同治疗组(B组,n=43)。A组仅对入选患者给予益生菌联合三联疗法进行根除治疗,而其配偶未给予治疗;B组患者及其配偶均给予益生菌联合三联疗法进行根除治疗。观察并记录两组患者的临床疗效,治疗前后血清超敏C反应蛋白(hs-CRP)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)水平的变化情况,以及Hp根除及复发情况。结果 B组患者的Hp根除率为88.4%(38/43),显著高于A组的62.8%(27/43);B组患者的复发率为13.2%(5/38),明显低于A组的37.0%(10/27);两组比较,差异均有统计学意义(P<0.05)。两组患者治疗14 d后及治疗结束30 d后的血清hs-CRP、IL-2及IL-6水平均显著改善,与治疗前比较,差异有统计学意义(P<0.05);B组治疗14 d后的上述指标与A组比较,差异无统计学意义(P>0.05);B组治疗结束30 d后的上述指标水平均显著优于A组,两组比较,差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论配偶双方同时治疗相比于单方治疗,可以显著提高Hp的根除率,降低复发率,并能更有效改善患者血清炎症因子水平。Objective To investigate the efficacy of probiotics combined with triple therapy in the treatment of helicobacter pylori（ Hp） infection in both spouses and the effect of unilateral treatment and the level of serum inflammatory factors. Methods A retrospective study was performed on 86 cases of patients with Hp infection who were admitted from January 2016 to January 2017. All conform to the standard of patients according to the will of the patients themselves and their spouses,patients were divided into Group A（ only patients received treatment,n = 43） and Group B（ the patients treated with their spouses,n = 43）. Patients in Group A were given probiotics combined with triple therapy for eradication treatment,their spouses were not given any treatment; the others in Group B were given robiotics combined with triple therapy together with their spouses. The clinical curative effect of two groups of patients,before and after treatment serum hypersensitive C-reactive protein（ hs-CRP） and interleukin-2（ IL-2） and interleukin-6（ IL-6） changes of the levels,and Hp eradication and relapse were recorded and analyzed. Results In Group B,Hp eradication rate 88. 4%（ 38/43）was significantly higher than 62. 8%（ 27/43） in Group A; the recurrence rate of Group B 13. 2%（ 5/38） was significantly lower than37. 0%（ 10/27） in Group A,and the differences were statistically significant（ P〈0. 05）. The serum hs-CRP,IL-2 and IL-6 significantly improved 14 days and 30 days after the treatment in both groups,compared to those before treatment,the difference was statistically significant（ P〈0. 05）; the indexes of Group B after 14 days of treatment had no statistically significant difference（ P〉0. 05）; the index of Group B after 30 days of treatment,the index level were significantly better than those of Group A（ P〈0. 05）; incidence rate of two groups of patients with adverse reaction had no statistically significant difference（ P〉0. 05）. Conclusion Compared with unilateral

关 键 词：幽门螺杆菌 配偶 益生菌 三联疗法 血清炎症因子 

分 类 号：R573.1[医药卫生—消化系统]