Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production  

作　　者：FU Qiang YANG Min MA Yu CHEN Jiang YUAN Hai-Mei 

机构地区：[1]College of Pharmacy and Biological Engineering, Chengdu University

出　　处：《Chinese Journal of Natural Medicines》2018年第2期131-138,共8页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81503234)

摘　　要：Four new triterpene saponins, mandshunosides F–I(1–4), together with five known compounds(5–9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin(3–9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%– 64.6% at 50 μmol·L^(-1), whereas monodesmosidic saponins with a free carboxyl group at C-28(1 and 2) showed potent inhibitory activities with IC_(50) values being 12.7 and 8.3 μmol·L^(-1), respectively.Four new triterpene saponins, mandshunosides F–I（1–4）, together with five known compounds（5–9）, were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin（3–9） showed modest suppression of NO production with the inhibition ratios in the range of 51.3%– 64.6% at 50 μmol·L^（-1）, whereas monodesmosidic saponins with a free carboxyl group at C-28（1 and 2） showed potent inhibitory activities with IC_（50） values being 12.7 and 8.3 μmol·L^（-1）, respectively.

关 键 词：CLEMATIS mandshurica TRITERPENE SAPONINS Mandshunosides F—I NO production 

分 类 号：R284[医药卫生—中药学]