非糜烂性反流病相关危险因素分析  

Related risk factors of non-erosive reflux disease

作　　者：王轶[1] 朱生樑[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院消化科,200437

出　　处：《国际消化病杂志》2018年第1期32-36,共5页International Journal of Digestive Diseases

基　　金：上海市科委科技支撑项目(13401902800)

摘　　要：目的探讨非糜烂性反流病(NERD)的相关危险因素。方法选择2015年9月至2017年3月在上海中医药大学附属岳阳中西医结合医院就诊的100例NERD患者作为病例组,同期100名健康体检者作为对照组,收集研究对象的一般资料、饮食习惯、生活方式、精神心理状态、胃肠道疾病家族史等情况,分析上述因素对NERD发病的影响。结果单因素分析显示,病例组与对照组在性别、甜食、生冷、辛辣、饮酒、咖啡、进食过饱、吸烟、焦虑、抑郁、胃肠道疾病家族史方面的暴露率不同,差异有统计学意义(P<0.05),提示上述11个变量与NERD发病相关。多因素Logistic逐步回归分析显示,年龄(X2:P=0.001,OR=1.85)、生冷(X7:P=0.027,OR=5.47)、辛辣(X8:P=0.027,OR=3.36)、咖啡(X12:P=0.064,OR=3.34)、进食过饱(X13:P<0.001,OR=9.98)、焦虑(X18:P=0.001,OR=4.09)、抑郁(X19:P=0.006,OR=2.21)、胃肠道疾病家族史(X20:P<0.001,OR=24.93)是NERD发病的危险因素。结论喜食生冷、辛辣、咖啡、进食过饱、焦虑、抑郁、胃肠道疾病家族史是NERD发病的独立危险因素。针对高危人群,节制饮食和改善情绪对防治NERD有重要意义。Objective This paper intends to explore the related risk factors of non-erosive reflux disease(NERD).Methods The 100 outpatients who visited Yueyang Hospital of Integrated Traditional Chinese and Western Medicine from Sep.2015 to Mar.2017 were assigned to the NERD group while100 healthy people were assigned to the control group.The general condition,dietary habits,lifestyles,mental status,and family histories of the patients were collected to explore their effects on the incidence of NERD.Results The univariate analysis indicated that there was a statistical difference between the NERD group and the control group in the exposure rate of gender,sweets,raw or cold food,spicy food,alcohol,coffee,overeating,smoking,anxiety,depression,and family history of gastrointestinal diseases(P<0.05);the above 11 variables were associated with the onset of NERD.The multivariate logistic stepwise regression analysis suggested that when put into the logistic regression equation,variables such as age(X2:P=0.001,OR=1.85),raw or cold food(X7:P=0.027,OR=5.47),spicy food(X8:P=0.027,OR=3.36),coffee(X12:P=0.064,OR=3.34),overeating(X13:P<0.001,OR=9.98),anxiety(X18:P=0.001,OR=4.09),depression(X19:P=0.006.OR=2.21),and family history of gastrointestinal diseases(X20:P<0.001,OR=24.93)were the risk factors for NERD.Conclusions Raw or cold food,spicy food,coffee,overeating,anxiety,depression,and familyhistory of gastrointestinal diseases are the independent risk factors for NERD.Therefore,it is of great significance for high-risk groups to diet and improve mood for the prevention and treatment of NERD.

关 键 词：非糜烂性反流病 危险因素 饮食 心理 LOGISTIC 回归 

分 类 号：R571[医药卫生—消化系统]