人表皮生长因子受体-2和细胞增殖抗原Ki67与乳腺癌前哨淋巴结转移的关系分析  

Analysis of the relationship between human epidermal growth factor receptor-2, cell proliferating antigen Ki67 and sentinel lymph node metastasis of breast cancer

作　　者：白晓蓉[1] 杨碎胜[1] 高晨[1] 

机构地区：[1]甘肃省肿瘤医院,730050

出　　处：《中国实用医药》2018年第6期8-9,共2页China Practical Medicine

基　　金：2011年甘肃省卫生行业科研计划管理项目(项目编号:GWGL2011-8)

摘　　要：目的分析人表皮生长因子受体-2(HER-2)和细胞增殖抗原Ki67与乳腺癌前哨淋巴结转移的关系。方法 238例乳腺癌患者,获取组织样本后送检实验室,检测分析HER-2和细胞增殖抗原Ki67的阳性表达情况,及其与病理特征之间的关系。结果 238例乳腺癌患者的HER-2及细胞增殖抗原Ki67阳性表达率分别为66.81%(159/238)及76.47%(182/238)。TNM分期及前哨淋巴结有无转移与HER-2阳性表达有关(P<0.01);TNM分期及前哨淋巴结有无转移与细胞增殖抗原Ki67表达情况有关(P<0.01)。结论 HER-2和细胞增殖抗原Ki67与乳腺癌前哨淋巴结转移有关,临床效果较好。Objective To analyze the relationship between human epidermal growth factor receptor-2（HER-2）, cell proliferation antigen Ki67 and sentinel lymph node metastasis of breast cancer. Methods The tissue samples of 238 breast cancer patients were sent to the laboratory to detect the positive expression of HER-2 and cell proliferation antigen Ki67, and its relationship with pathological features. Results The positive expression rates of HER-2 and cell proliferation antigen Ki67 in 238 cases of breast cancer were 66.81%（159/238） and 76.47%（182/238） respectively. TNM staging and the metastasis of sentinel lymph nodes were related to the positive expression of HER-2（P〈0.01）. TNM staging and the metastasis of sentinel lymph nodes were related to the expression of cell proliferation antigen Ki67（P〈0.01）. Conclusion HER-2 and cell proliferation antigen Ki67 are related to the sentinel lymph node metastasis of breast cancer, and the clinical effect is good.

关 键 词：人表皮生长因子受体-2 细胞增殖抗原Ki67 乳腺癌 前哨淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]