艾迪注射液联合PC化疗方案对晚期非小细胞肺癌患者骨髓抑制及生活质量的影响  

Effect of Addie injection combined with PC chemotherapy on bone marrow suppression and quality of life in patients with advanced non-small cell lung cancer

作　　者：郭文娟[1] 张冠磊[1] 李均[2] 

机构地区：[1]河南科技大学第二附属医院呼吸内科,河南洛阳471000 [2]中国航空工业集团公司洛阳电光设备研究所职工医院内科,河南洛阳471000

出　　处：《医药论坛杂志》2017年第11期46-48,共3页Journal of Medical Forum

摘　　要：目的探究艾迪注射液联合PC化疗方案对晚期非小细胞肺癌(NSCLC)患者骨髓抑制及生活质量的影响。方法选取2012年2月—2017年5月河南科技大学第二附属医院87例晚期NSCLC患者,随机数字表法分组,对照组43例,予以PC化疗(紫杉醇+卡铂),研究组44例,予以艾迪注射液+紫杉醇+卡铂,两组均持续治疗2个周期。统计对比两组治疗效果、骨髓抑制发生率、生活质量评分(SF-36)。结果经秩和检验,研究组治疗有效率为61.36%(27/44),高于对照组34.88%(15/43),差异有统计学意义(P<0.05);治疗后研究组精神状态、生理职能、躯体疼痛、社会功能、健康状况评分高于对照组,差异有统计学意义(P<0.05);研究组骨髓抑制发生率为38.63%(17/44),低于对照组67.44%(29/43),差异有统计学意义(P<0.05)。结论艾迪注射液联合PC化疗方案可降低晚期NSCLC患者骨髓抑制发生率,提高治疗效果及生活质量。Objective To investigate the effect of Addie injection combined with PC chemotherapy on bone marrow suppression and quality of life in patients with advanced non-small cell lung cancer（NSCLC）.Methods 87 patients with advanced NSCLC from February 2012 to May 2017 in the Second Affiliated Hospital of Henan University of Science and Technology were randomly divided into groups.43 cases in the control group were treated with PC chemotherapy（paclitaxel combined with carboplatin）,and 44 cases in the study group were given Addie injection combined with paclitaxel and carboplatin.The two groups were treated for two cycles continuously.The curative effect,the bone marrow suppression rate and the quality of life（SF-36） score were compared between the two groups.Results The rank sum test showed that the effective rate of treatment in the study group was 61.36%（27/44） was higher than that of the control group（34.88%）（15/43）.The difference was statistically significant（P 0.05）.After treatment,the scores of mental status,physical function,physical pain,social function and health status of the study group were higher than those of the control group.The difference was statistically significant（P 0.05）.The incidence of bone marrow suppression in the study group was 38.63%（17/44）,which was lower than that of the control group（67.44%）（29/43）.The difference was statistically significant（P 0.05）.Conclusion Addie injection combined with PC chemotherapy can reduce the incidence of bone marrow depression in patients with advanced NSCLC and improve the treatment effect and quality of life.

关 键 词：艾迪注射液 卡铂 紫杉醇 晚期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]