不同糖尿病风险评分在体检人群中应用的效果评价  被引量:9

Comparison of different diabetic risk score in health check-up population

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作  者:王蕾蕾[1] 潘洁[1] 曹素艳[1] 郭立新[2] 

机构地区:[1]北京医院特需医疗部国家老年医学中心,100730 [2]北京医院内分泌科国家老年医学中心,100730

出  处:《中华糖尿病杂志》2018年第2期123-127,共5页CHINESE JOURNAL OF DIABETES MELLITUS

摘  要:目的探讨不同糖尿病风险评分在体检人群中筛查糖尿病的效果,分析体检人群糖代谢异常的危险因素。方法对2015年北京医院体检中心的体检人群进行糖尿病风险评分筛查,用受试者工作特征曲线下面积(AUC)反映筛查方法的准确度;通过多因素Logistic回归分析糖代谢异常者的各种相关危险因素。结果(1)中国糖尿病风险评分(C-DRs)的AUC为0.83[95%可信区间(95%CI)0.811-0.843],最佳切点值为26.5分时,灵敏度83.48%,特异度61.45%,约登指数为0.45(P〈0.05)。(2)年龄≥50岁[比值比(OR)=2.646,95%CI:1.707-4.101]、糖尿病家族史(OR=13.103,95%CI:6.076-28.259)、BMI≥25 kg/m^2(OR=2.400,95%CI:1.609-2.580)、男性腰围≥90 cm(OR=3.869,95%CI:1.687-8.872)、女性腰围≥85 cm(OR=1.787,95%CI:1.183-2.699)、高血压(OR=7.812,95%CI 1.560-39.113)、高甘油三酯(TG)(≥1.7 mmol/L)(OR=1.751,95%CI:1.138-2.696)、吸烟史(OR=3.974,95%CI 2.085-7.474)、每周中等强度活动量〈150 min(OR=10.446,95%CI:5.304-20.574)、每餐主食量100 g以上(OR=58.581,95%CI:24.899-137.826)是糖代谢异常的危险因素(均P〈0.05)。(3)综合以上危险因素对体检人群进行糖尿病筛查,得出AUC为0.88(95%CI:0.862-0.890),最佳切点值为31.5分时,灵敏度88.60%,特异度68.68%,约登指数为0.57(P〈0.05)。结论C-DRs适用于中国体检人群糖尿病的筛查;每周中等强度活动量〈150 min、每餐主食量100 g以上、吸烟史、高TG等危险因素可提高C-DRs筛查糖尿病的灵敏度和特异度。Objective To explore the effect of different diabetic risk score in screening for diabetes mellitus in the health check-up population, and to analyze the risk factors of abnormal glucose metabolism.Methods Diabetes risk scores screening was conducted in people who participated physical examination in Medical Examination Center of Beijing Hospital in 2015. The area under the curve (AUC) of the receiver operating characteristic curve was used to reflect the accuracy of the screening method. The relevant risk factors of abnormal glucose metabolism were used by multivariate logistic regression analysis.Results (1) The AUC of screening for diabetes by Chinese diabetes risk score (C-DRs) was 0.83 [95% confidence interval (CI) 0.811-0.843], and the best cut-point value was 26.5. The sensitivity was 83.48%, the specificity was 61.45%, and the Younden index was 0.45 (P〈0.05). (2) Age [odds ratio (OR)=2.646, 95%CI: 1.707-4.101], family history of diabetes (OR=13.103, 95%CI: 6.076-28.259), BMI≥25 kg/m^2 (OR=2.400, 95%CI: 1.609-2.580), male abdominal circumference≥90 cm (OR=3.869, 95%CI: 1.687-8.872), female abdominal circumference≥85 cm (OR=1.787, 95%CI: 1.183-2.699), hypertention (OR=7.812, 95%CI: 1.560-39.113), high triglyceride (TG) (≥1.7 mmol/L) (OR=1.751, 95%CI: 1.138-2.696), smoking history (OR=3.974, 95%CI: 2.085-7.474), less than 150 min moderate physical activity per week (OR=10.446, 95%CI: 5.304-20.574), more than 100 g carbohydrates per meal (OR=58.581, 95%CI: 24.899-137.826) were risk factors for abnormal glucose metabolism (all P〈0.05). (3) In combination with the above risk factors used to screen for diabetes, the AUC was 0.88 (95%CI: 0.862-0.890), the best cut-point value was 31.5, the sensitivity was 88.60%, the specificity 68.68%, the Jordanian index was 0.57 (P〈0.05).Conclusions C-DRs is more suitable for diabetes screening in Chinese population. Combined with the factors as: less t

关 键 词:葡萄糖代谢障碍 危险因素 糖尿病风险评分 

分 类 号:R363.2[医药卫生—病理学]

 

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