乳腺癌细胞中AIP1/YAP/TAZ的表达及临床意义  

Expression and clinical significance of AIP1/YAP/TAZ in breast cancer cell

作　　者：杨昱[1] 贾真 

机构地区：[1]中国医科大学附属第一医院血管外科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2018年第7期989-991,共3页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81402088)

摘　　要：目的:通过检测乳腺癌4T1细胞系中AIP1/YAP/TAZ的表达量及敲除AIP1后YAP/TAZ表达量的差异,为乳腺癌寻找新的生物标志物和治疗手段。方法:选取乳腺癌4T1细胞系,通过RT-PCR及Western-Blot检测AIP1/YAP/TAZ的表达量及其差异。结果:AIP1/YAP/TAZ在乳腺癌中均有表达,且敲除AIP1后YAP表达量明显减少(P<0.05),TAZ表达量也减少。结论:AIP1/YAP/TAZ可作为一种潜在的生物标志物来预测乳腺癌的恶性程度,为探索乳腺癌的治疗提供新的方向。Objective：To detect the expression of AIP1/YAP/TAZ in breast cancer 4T1 cell line and the different expressions of YAP/TAZ after AIP1 knockdown,so as to find a new biomarker and therapeutic method for breast cancer.Methods：4T1 cell line was selected and the expression of AIP1/YAP/TAZ and its difference were detected by RT-PCR and Western-Blot.Results：AIP1/YAP/TAZ was expressed in breast cancer,and the expression of YAP was significantly decreased after AIP1 knockdown （P〈0.05）,and the expression of TAZ was also decreased.Conclusion：AIP1/YAP/TAZ can be used as a potential biomarker to predict the malignancy of breast cancer and provide a new direction for the treatment of breast cancer.

关 键 词：AIP1/YAP/TAZ 4T1细胞系 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]