LIMD2蛋白及E钙黏素在非小细胞肺癌中的表达及其临床意义  

The expression of LIMD2 and E-cadherin and clinical significance in NSCLC

作　　者：刘明东 赵忠全[2] 王富成[1] 蔡月银 黄威 屈天生[1] 

机构地区：[1]福州总医院442临床部,福建福州352100 [2]福州总医院肿瘤科,福建福州350000

出　　处：《现代肿瘤医学》2018年第8期1202-1206,共5页Journal of Modern Oncology

基　　金：福建省自然科学基金(编号:2016J01586)

摘　　要：目的:探讨含LIM域2(LIM domain containing 2,LIMD2)蛋白及E钙黏素(E-cadherin)在非小细胞肺癌(NSCLC)中的表达及临床意义。方法:采用免疫组化法对141例NSCLC肿瘤组织和25例癌旁组织中的LIMD2蛋白及E钙黏素进行检测。SPSS 21进行统计学分析,P<0.05认为差异有统计学意义。结果:LIMD2在肿瘤组织中高表达71例(50.4%),低表达70例(49.6%);在癌旁组织中高表达7例(28.0%),低表达18例(72.0%),LIMD2在肿瘤组织中高表达较癌旁组织常见。E钙黏素在肿瘤组织中高表达75例(53.2%),低表达66例(46.8%);在癌旁组织中高表达13例(52.0%),低表达12例(48.0%),E钙黏素在两种组织中表达无差异。肿瘤组织中LIMD2表达水平在不同N分期、TNM分期及肿瘤分化程度方面存在差异,LIMD2高表达常见于术后无病生存期(DFS)短的患者中(P=0.033)。E钙黏素表达水平在不同的T分期、N分期及TNM分期中存在差异,E钙黏素高表达在术后DFS较长的患者中常见(P=0.000)。在癌组织中LIMD2表达水平与E钙黏素表达水平呈负相关(P=0.000)。多因素回归分析表明性别、T分期、TNM分期、肿瘤分化程度、LIMD2及E钙黏素表达与NSCLC术后DFS相关。结论:在NSCLC中LIMD2与E钙黏素表达呈负相关,LIMD2在肿瘤组织中表达越高术后DFS越短,LIMD2或许可以作为预测NSCLC术后复发的生物标志物。Objective：To explore LIMD2 and E-cadherin expression and clinical significance in NSCLC.Methods：The expression levels of LIMD2 and E-cadherin in 141 cases of NSCLC carcinoma tissue and 25 cases of tissue adjacent to carcinoma were investigated by IHC.SPSS 21 was used to analyze and the statistical significance level was set at 0.05.Results：In the carcinoma tissue,71（50.4%） had high LIMD2 expression level,70（49.6%） had low level.In the tissue adjacent to carcinoma,7（28.0%） had high LIMD2 expression level,18（72.0%） had low level.LIMD2 expression level is different in the two kinds of tissue.In the carcinoma tissue,75（53.2%）had high E-cadherin expression level,66（46.8%） had low level.In the tissue adjacent to carcinoma,13（52.0%） had high E-cadherin expression level,12（48.0%） had low level.E-cadherin expression level is not different in the two kinds of tissue.LIMD2 expression correlated with the N stage,TNM stage and tumor differentiation.High LIMD2 expression level was more common in the shorter DFS patients（P=0.033）.E-cadherin expression correlated with the T stage,N stage and TNM stage.High E-cadherin expression level was more common in the better DFS patients（P=0.000）.High LIMD2 expression was related to low E-cadherin expression（P= 0.000）.Multivariate Cox regression analysis demonstrated that gender,T stage,TNM stage,tumor differentiation,LIMD2 and E-cadherin were related to DFS.Conclusion：LIMD2 negatively correlated with E-cadherin expression in NSCLC.The higher LIMD2 expression level in NSCLC tissue means shorter DFS after surgeon.LIMD2 may have a role in promoting NSCLC invasiveness and may be a promising biomarker for recurrence after surgeon.

关 键 词：LIMD2 非小细胞肺癌 无病生存期 生物标志物 

分 类 号：R734.2[医药卫生—肿瘤]