益母草冲剂对Ⅲ-Ⅳ期宫颈癌放疗患者近期疗效及毒副反应的影响  

Clinical observation of the effect and side effect of Leenurus heterophyllus on radiotherapy for stage Ⅲ and stage Ⅳ cervical cancer patients

作　　者：刘丹[1] 李志斌[1] 钟世寿 李国苗[1] 

机构地区：[1]内江市第二人民医院,四川内江641000

出　　处：《现代肿瘤医学》2018年第8期1256-1259,共4页Journal of Modern Oncology

基　　金：四川省卫生和计划生育委员会基金资助项目(编号:150090)

摘　　要：目的:观察Ⅲ-Ⅳ期宫颈癌单纯放疗的患者,放疗过程中口服益母草冲剂对放疗疗效及毒副反应的影响。方法:2014年6月至2016年12月收治的116例单纯行宫颈癌放疗的患者,随机分成治疗组(n=45)和对照组(n=71)。对照组:放疗均采用逆向调强放疗即IMRT联合后装放疗。治疗组:放疗均采用逆向调强放疗联合后装放疗,放疗期间(从放疗第一天开始至后装放疗最后一次结束)口服益母草冲剂,温水冲服,一次5克,早晚各1次。患者完成放疗后4~6周内影像学复查进行评估。结果:治疗组有效39例(86.67%),对照组有效41例(57.75%),差异具有统计学意义(P=0.001)。其中Ⅲ期治疗组有效14例,对照组有效15例,治疗组有效率明显高于对照组,差异具有统计学意义(P=0.039)。Ⅳ期治疗组有效25例,对照组有效26例,治疗组有效率明显高于对照组,差异具有统计学意义(P=0.038)。在放射性直肠炎、放射性膀胱炎和骨髓抑制的毒副反应方面,两组差异无统计学意义。结论:益母草冲剂能有效增加晚期宫颈癌患者放疗的近期疗效,且未增加放疗毒副反应。其作用机制可能与其活血化瘀机理有关,有望成为宫颈癌优良的放疗增敏剂。Objective：To observe the effect of oral administration of Leenurus heterophyllus on the efficacy and adverse effects of radiotherapy in patients with stage III-IV radiotherapy alone for cervical cancer.Methods：116 patients who received radiotherapy alone for cervical cancer in June 2014 to December 2016 were randomly divided into treatment group （45 cases） and control group （71 cases）.Control group：Radiotherapy was performed by reverse intensity-modulated radiotherapy（IMRT） combined with brachytherapy.Experimental group：Radiotherapy was performed by IMRT combined with brachytherapy.Oral Leenurus heterophyllus was administered with warm boiling water during radiotherapy（from the first day of radiotherapy to the last brachytherapy）,5 g/time,two times a day.The patient was assessed for radiographic imaging within 4~6 weeks after completion of radiotherapy.Results：The treatment group was effective in 39 cases （86.67%）,the control group was effective in 41 cases （ 57.75%）,the difference was statistically significant （P=0.001）.Phase III treatment group was effective in 14 cases,control group 15 cases were effective,the effective rate of the treatment group was significantly higher than the control group,the difference was statistically significant （P=0.039）.Phase IV treatment group 25 cases,control group 26 cases,the treatment group was significantly higher than the control group,the difference has statistical significance （P=0.038）.There were no statistically significant differences in adverse reactions （radiation proctitis,radiocystitis and bone marrow suppression） between the two groups.Conclusion：Leenurus heterophyllus can effectively increase the short-term effect of radiotherapy in patients with advanced cervical cancer,and did not increase the adverse effects of radiotherapy.Mechanism may be related to the mechanism of promoting blood circulation to dissipate blood stasis.It is expected to be a good sensitizer for radiotherapy of cervical cancer.

关 键 词：益母草 宫颈癌 放疗敏感性 

分 类 号：R737.3[医药卫生—肿瘤]