一氧化氮与内皮素在肝硬化发生发展中的作用  

The roles of nitric oxide and endothelin in development of hepatic cirrhosis

作　　者：郭俊芝[1] 袁佩英[2] 韩德五[3] 

机构地区：[1]山西医科大学第一医院,山西太原030001 [2]山西医科大学第二医院,山西太原030001 [3]山西医科大学肝病研究所,山西太原030001

出　　处：《临床医药实践》2002年第7期487-490,共4页Proceeding of Clinical Medicine

摘　　要：目的 :研究一氧化氮和内皮素在肝硬化发生发展中的作用。方法 :用放射免疫法 ,镀铜镉还原法和火箭电泳法测定 74例肝硬化患者和 5 1例正常对照组血浆内皮素 (ET)、肿瘤坏死因子 α(TNFα)、一氧化氮 (NO)和纤维联结蛋白 (FN)的含量。结果 :肝硬化患者血浆 ET和 NO明显升高 ,二者均与 TNFα呈正相关 ,与 FN呈负相关。ET和 NO水平随肝功能受损加重、腹水量增加和食管静脉曲张程度加重而增加 ,正常对照组和肝硬化 A级时 ,ET与 NO无相关性 ,而 B级和 C级 ,中大量腹水组及食管静脉曲张组 ET和 NO呈明显正相关。结论 :NO和 ET在肝硬化发生发展中均具有重要作用 。Objective:To study the roles of plasma endothelin and nitric oxide in development of hepatic cirrhosis.Methods:The plasma levels of endothelin(ET) and tumor necrosis factor α(TNFα) were measured using radioimmunoassay in 74 patients with cirrhosis and 51 normal controls,meanwhile nitric oxide(NO)and fibronectin(FN) were measured by a coopercoated cadimium method and a rocket electrophoresis method,respectively.Results:The plasma levels of ET and NO were significantly increased in cirrhotic patients compaired with normal controls.Both ET and NO showed a positive correlation with TNFα and a negative correlation with FN.Additionally,the plasma ET and NO levels were increased and associated with severity of liver damage,or elevation of ascites or development of esophageal varices.There was no correlation between NO and ET in normal control and according to child-pugh group of class A in cirrhotic patients.However,a significantly positive correlation in group of class B and C,or middle and large quantity of ascites or esophageal varices.Conclutions:NO and ET played important roles in the deveplopment of hepatic cirrhosis,and synergistic effects on the decompensation and complication formation in cirrhotic patients.

关 键 词：一氧化氮 内皮素 肝硬化 肿瘤坏死因子Α 纤维联结蛋白 

分 类 号：R575.2[医药卫生—消化系统]