益生菌辅助抗生素对非胆源性SAP患者炎性细胞因子及生存质量的影响  

Effect of probiotics plus antibiotics on inflammatory cytokines and quality of life in patients with non-biliary severe acute pancreatitis

作　　者：方晶晶[1] 黄钦 史超路[1] 陶静[1] 颜碧清[1] 盖磊 厉旭光[1] 

机构地区：[1]宁波大学医学院附属医院ICU,浙江省宁波市315020

出　　处：《世界华人消化杂志》2018年第4期270-275,共6页World Chinese Journal of Digestology

摘　　要：目的探讨益生菌辅助抗生素对非胆源性重症急性胰腺炎(severe acute pancreatitis,SAP)患者炎性细胞因子及生存质量的影响.方法选取我院2013-12/2017-09非胆源性SAP患者68例,随机数字表法分为对照组(n=34)与研究组(n=34).常规干预基础上对照组采取抗生素(头孢曲松+奥硝唑+庆大霉素),研究组于对照组基础上采取益生菌(双歧杆菌三联活菌),均治疗7 d.统计两组症状(血淀粉酶恢复正常、体温恢复正常、腹痛缓解、肛门排气)改善及住院时间、入院时及疗程结束后血清降钙素原(procalcitonin,PCT)、C反应蛋白(C-reaction protein,CRP)、白细胞介素-6(interleukin,I L-6)水平、生存质量(S F-36)分值、不良反应发生率.结果研究组血淀粉酶恢复正常、体温恢复正常、腹痛缓解用时及住院时间少于对照组(P<0.05);治疗前两组血清PCT、CRP、IL-6水平间无明显差异(P>0.05),治疗后两组血清PCT、CRP、IL-6水平较治疗前降低,且研究组低于对照组(P<0.05);治疗前两组SF-36分值间无明显差异(P>0.05),治疗后两组SF-36分值较治疗前增高,且研究组高于对照组(P<0.05);研究组不良反应发生率与对照组比较(14.71%vs 8.82%),无明显差异(P>0.05).结论联合采取益生菌及抗生素治疗非胆源性SAP可有效缓解患者临床症状,缩短其住院时间,降低血清炎性细胞因子水平,减轻体内炎症反应,提高患者生存质量,且不会增加不良反应发生风险,具有较高安全性.AIM To investigate the effect of probiotics plus antibiotics on inflammatory cytokines and the quality of life in patients with non-biliary severe acute pancreatitis （SAP）. METHODS A total of 68 patients with non-biliary SAP treated from December 2013 to September 2017 at our hospital were selected and divided into a control group （n = 34） and a study group （n = 34）. Both groups were given routine intervention and antibiotics （ceftriaxone ＋ ornidazole ＋ gentamycin）, and the study group was additionally given probiotics （Bifidobacterium triple live bacteria）. Both groups were treated for 7 d. The improvements of symptoms （time for blood amylase back to normal, time for body temperature back to normal, time to abdominal pain remission, and time to anal exhaust）, hospitalization time, serum levels of calcitonin （PCT）, C reactive protein （CRP）, and interleukin-6 （IL-6） at admission and after treatment, quality of life （SF-36） score, and the incidence of adverse reactions were statistically compared between the two groups. RESULTS Time for blood amylase back to normal, time for body temperature back to normal, time to abdominal pain remission, and hospitalization time were significantly shorter in the study group than in the control group （P 〈 0.05）. Before treatment, there was no significant difference in the levels of serum PCT, CRP, or IL-6 between the two groups. After treatment, the levels of serum PCT, CRP, and IL-6 in both groups were significantly lower than those before treatment, andthe decrease was significantly greater in the study group than in the control group （P 〈 0.05）. There was no significant difference between the two groups in SF-36 score before treatment. After treatment, the SF-36 scores in both groups were significantly higher than those before treatment, and SF-36 score in the study group was significantly higher than that in the control group （P 〈 0.05）. There was no significant difference in the incidence of adverse reactions betw

关 键 词：益生菌 抗生素 非胆源性SAP 炎性细胞因子 生存质量 

分 类 号：R576[医药卫生—消化系统]