肾上腺素受体阻滞剂对DEN诱发小鼠肝癌的治疗作用  

Therapeutic effect of adrenergic receptor blocker on liver cancer induced by DEN in mice

作　　者：梁玲 

机构地区：[1]临沂市妇女儿童医院,山东临沂276000

出　　处：《医药论坛杂志》2018年第1期35-36,39,共3页Journal of Medical Forum

摘　　要：目的探讨肾上腺素受体阻滞剂对二乙基亚硝铵(DEN)诱发小鼠肝癌的治疗作用。方法成功诱发肝细胞肝癌的32只小鼠随机分三组,酚妥拉明治疗组(A组)11只,普萘洛尔治疗组(B组)11只,对照组(C组)10只。结果 B组在肿瘤的大小、数量、肝/体比、生存期以及血清AFP水平方面与A、C组比较差异均有统计学意义(P<0.01),而A组与C组比较差异无统计学意义(P>0.05)。结论普萘洛尔对DEN诱发的小鼠肝癌有明显抑制作用。Objective To explore the therapeutic effect of adrenergic receptor blocker on liver cancer induced by N-Nitrosodiethylamine（ DEN） in mice. Methods Totally 32 HCC mice were randomly divided into three groups. 11 mice were assigned to the phentolamine treatment group（ group A）,11 mice was assigned to propranolol treatment group（ group B）,10 mice was assigned to the control group（ Group C）. Results Group B in the tumor size,tumo number,liver/body ratio,survival and serum AFP levels were significantly difference compared with group A and C（ P 〈0. 01）.But There was no significant difference between group A and C（ P 〉0. 05）. Conclusion Propranolol can significantly inhibit hepatocellular carcinoma in mice induced by DEN.

关 键 词：肾上腺素受体阻滞剂 普萘洛尔 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]