艾迪莎联合美沙拉嗪栓剂治疗溃疡性直肠炎患者临床疗效及对患者细胞因子和凝血功能影响  

Clinical efficacy of etiasa combined mesalazinesuppository in the treatment of ulcerative proctitis patients and its effect on cell factor and coagulation function

作　　者：尧小青 金瑞放[1] 苏林燕 

机构地区：[1]温州医科大学附属第一医院消化内科,浙江温州325000

出　　处：《中国中西医结合消化杂志》2018年第2期190-193,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]探讨艾迪莎联合美沙拉嗪栓剂治疗溃疡性直肠炎患者临床疗效及对患者细胞因子和凝血功能的影响。[方法]选自我院于2016年3月~2017年3月期间收治的溃疡性直肠炎患者98例,按照随机表法分为观察组49例与对照组49例。对照组给予美沙拉嗪栓剂治疗,观察组在对照组基础上结合艾迪莎治疗。2组疗程均为4周。比较2组治疗疗效,治疗前后主要症状积分、细胞因子和凝血功能指标变化。[结果]观察组治疗总有效率(93.88%)高于对照组(75.51%)(P<0.05)。2组治疗后腹痛、腹泻和里急后重积分降低(P<0.05);观察组治疗后腹痛、腹泻和里急后重积分低于对照组(P<0.05)。2组治疗后血清IL-4增加而IL-6和TNF-α水平降低(P<0.05);观察组治疗后血清IL-4高于对照组而IL-6和TNF-α水平低于对照组(P<0.05)。2组治疗后D-D和PLT水平降低(P<0.05);且观察组低于对照组(P<0.05)。[结论]艾迪莎联合美沙拉嗪栓剂治疗溃疡性直肠炎患者临床疗效明显,且可改善患者微炎症状态及凝血功能,具有重要研究价值。[Objective]To explore the clinical efficacy of etiasa combined mesalazine suppository in the treatment of ulcerative proctitis patients and its effect on cell factor and coagulation function.[Methods]98 cases of ulcerative proctitis patients were selected from our hospital during the period from March 2016 to March 2017,randomly divided into observation group and control group（n=49 in each）.The control group was treated with mesalazine suppository,and the observation group was treated with etiasa combined mesalazine suppository.The two groups were treated for 4 weeks.The therapeutic effect,the main symptom scores,the changes of cytokines and coagulation function indexes before and after treatment were compared between two groups.[Results]The total effective rate of the observation group（93.88% ）was higher than that of the control group（75.51% ）（P0.05）.Abdominal pain,diarrhea and tenesmus score decreased in two groups after treatment（observation group：t=22.1175,19.5513,26.4094,control group：t=9.4541,12.0130,13.1201,P0.05）;abdominal pain,diarrhea and tenesmus score of the observation group after the treatment was lower than that of the control group（t=22.6722,17.9396,19.3115,P0.05）.The two groups after treatment of serum IL-4 increased IL-6 and TNF-αlevels decreased（the observation group：t=11.8961,27.3087,29.7986,the control group：t=5.8183,16.7994,13.1329,P0.05）;the observation group after treatment,serum IL-4 was higher than the control group and the IL-6 and TNF-αlevels were lower than the control group（t=7.2642,13.0384,18.4502,P0.05）.D-D and PLT levels decreased intwo groups after treatment（observation group：t=19.2078,20.1096,control group：t=6.5099,9.6857,P0.05）;D-D and PLT levels after treatment were lower than those of the control group（t=8.4034,13.3176,P0.05）.[Conclusion]Etiasa combined mesalazine suppository in the treatment of ulcerative proctitis patients has obvious clinical curative effect,and can improve patients with micro inflammatory state and coa

关 键 词：艾迪莎 美沙拉嗪栓剂 溃疡性直肠炎 细胞因子 凝血功能 

分 类 号：R574.63[医药卫生—消化系统]