肾透明细胞癌组织中趋化因子CXC配体3的表达及意义  

Expression and significance of CXC chemokine ligand 3 in renal cell carcinoma tissues

作　　者：齐亚灵[1] 李玥[2] 隋洪玉[2] 杨哲[2] 逄德志 张泽宇 向雨 贾琳琳[2] 王伟群[2] 

机构地区：[1]海南医学院 [2]佳木斯大学基础医学院,黑龙江佳木斯154002

出　　处：《中国老年学杂志》2018年第5期1185-1187,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金项目(No.81272854); 黑龙江省自然科学基金项目(No.D200966); 黑龙江大学生创新创业训练计划项目(201710222003); 佳木斯大学研究生科技创新项目(YM2016_006);佳木斯大学校长创新创业基金项目(xzyf2017-30); 海南医学院引进人才科研启动基金(2017002)

摘　　要：目的研究趋化因子CXC配体(L)3在肾透明细胞癌及癌旁组织的表达差异,探讨CXCL3表达与肾透明细胞癌临床病理参数的相关性。方法利用免疫组织化学染色方法检测肾脏组织芯片中CXCL3的表达。结果与肾透明细胞癌组织比较,癌旁组织CXCL3表达量显著提高(P=0.000);癌组织和癌旁组织肾透明细胞癌Ⅲ级组织CXCL3表达水平均显著高于Ⅱ级(P=0.044;P=0.037);CXCL3表达水平与肾透明细胞癌临床病理参数无相关性。结论 CXCL3表达水平与肾透明细胞癌临床分级呈正相关,其可能主要经旁分泌机制参与肾透明细胞癌进程。Objective To investigate the expression difference of CXC chemokine ligand（CXCL）3 in renal clear cell carcinoma and its adjacent tissues,and to explore the correlation between CXCL3 expression and clinical pathological parameters in renal clear cell carcinoma. Methods The expression of CXCL3 in renal tissue microarray was detected by immunohistochemical staining. Results The CXCL3 expression level in the tissues adjacent to carcinoma was increased significantly as compared with renal clear cell carcinoma tissues（ P = 0.000）; whether cancer tissues or tissues adjacent to carcinomas tissues,the CXCL3 expression level in grade Ⅲ renal clear cell carcinoma tissues were significantly higher as compared with grade Ⅲ（ P = 0.044;P = 0.037）;There was not relevance between CXCL3 expression level and clinical pathological parameters of renal clear cell carcinoma. Conclusions CXCL3 expression level was positively correlated with clinical classification in renal clear cell carcinoma,which may primarily participate in the process of renal clear cell carcinoma through a paracrine mechanism.

关 键 词：肾透明细胞癌 CXC趋化因子配体3 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]