98例口腔黏膜良性淋巴组织增生病的临床病理分析  

Clinicopathological analysis of 98 cases of benign lymphoidenosis of oral mucosa

作　　者：侯亚丽[1] 张昊[2] 郝亚丽 杨艳霄 李荷香[1] 

机构地区：[1]河北医科大学口腔医学院病理科·河北省口腔医学重点实验室,石家庄050017 [2]河北医科大学口腔医学院口腔颌面外科,石家庄050017

出　　处：《中华口腔医学杂志》2018年第3期191-194,共4页Chinese Journal of Stomatology

摘　　要：目的探讨口腔黏膜良性淋巴组织增生病（benign lymphoadenosis of oral mucosa，BLOM）的临床表现、病理变化及两者的关系，为BLOM的诊断提供参考。方法回顾分析河北医科大学口腔医学院病理科资料库中2004年1月至2016年12月最终诊断为BLOM的98例临床病例资料，男性31例，女性67例，分析其临床及病理表现。结果64％（63／98）的BLOM临床表现为黏膜糜烂溃疡，9％（9／98）临床表现为结节状突起。临床误诊率高达98％（96／98）。最终确诊为BLOM的病例中51％的病例上皮内有中性粒细胞浸润，固有层炎细胞成分复杂，83％的病例中淋巴细胞呈弥漫浸润。结论黏膜同有层炎细胞成分复杂，淋巴细胞呈弥漫、灶状浸润，或无糜烂溃疡的黏膜上皮内有中性粒细胞浸润时，需高度怀疑BLOM，寻找淋巴滤泡或淋巴细胞的灶状聚集，有助于正确诊断。Objective To investigate the clinical manifestations and pathological changes of benign lymphoadenosis of oral mucosa. Methods The clinical data of 98 cases of benign lymphoadenosis of oral mucosa were analyzed. Results The clinical manifestations of benign lymphoadenosis of oral mucosa included erosive ulcer（64%） and nodule （9%）and the rate of misdiagnosis was 98%. Neutrophil infiltration occurred in the epithelium of 51% cases and the lymphocyte was diffusely infiltrated in lamina propria of 83% cases. Conclusions When the mucous membrane of the lamina propria is characterized by complex cell components, diffuse infiltrating lymphocytes and infiltration of neutrophils in mucosal epithelium without erosion and ulceration, it is necessary to highly suspect benign lymphoadenosis of oral mucosa. Finding the focal aggregation of lymphoid follicles or lymphocytes is helpful for the correct diagnosis.

关 键 词：癌前状态 口腔黏膜 病理学 口腔 黏膜良性淋巴组织增生病 

分 类 号：R781.5[医药卫生—口腔医学]