尿源性干细胞及其在口腔医学组织工程中的应用前景  

Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration.

作　　者：瞿姣姣 王帅 吴家媛[2,3] 

机构地区：[1]遵义医学院,贵州遵义563000 [2]遵义医学院附属口腔医院,贵州遵义563000 [3]贵州省高等学校口腔疾病研究特色重点实验室,贵州遵义563000

出　　处：《口腔医学研究》2018年第2期206-208,共3页Journal of Oral Science Research

基　　金：贵州省科学技术基金计划(编号:黔教合基础[2016]1170);贵州省口腔医学研究生创新基地项目(编号:黔科研合CXJD字(2014)005);贵州省高等学校特色重点实验室建设项目(编号:黔教合KY字[2013]109)

摘　　要：尿源性干细胞(Urine-derived stem cells,USCs)是存在于尿液中,具有高度增殖性、自我更新能力、多向分化潜能及旁分泌特性的一种成体干细胞。作为一种新型的细胞来源,USCs储备丰富,取材容易,具有极佳的可行性和安全性。USCs利用其多向分化潜能和旁分泌特性参与组织再生的研究,已在临床前动物模型中取得一定成果。其研究成果均展示了USCs在口腔组织工程中的应用潜能。本文就其应用前景作一综述。Urine-derived stem cells（USCs）are novel adult stem cells existing in urine which possesses highly expandability,self-renewal capacity,paracrine properties,and multi-differentiation potential.In tissue regeneration,as a new source of cells,the USCs have excellent feasibility and safety.Most importantly,the body has a substantial source of USCs,which can be harvested easily in a non-invasive manner,regardless of the age,sex,and health condition of patients.USCs have been used in preclinical animal models to repair or regenerate tissue,employing either trans-differentiation or paracrine effects to stimulate endogenous cells participating in tissue regeneration.The potential application of USCs in oral maxillofacial tissue regeneration is reviewed in this paper.

关 键 词：尿源性干细胞 组织工程 牙再生 

分 类 号：R78[医药卫生—口腔医学]