T3、T4期鼻咽癌IMRT中海马受量相关性分析  被引量:4

Dose analysis of hippocampus in T3, T4 nasopharyngeal carcinoma patients treated with intensity modulated radiotherapy

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作  者:孙宗文 石磊[2] 孔月[3] 杜峰磊 谢铁明[2] 陈梦圆[4] 朱子羽 花永虹[3] 胡巧英[3] 陈晓钟[3] 陈媛媛[3] 陈明[1] Sun Zongwen , Shi lei , Kong yue , Du fenglei , Xie Tieming , Zhu Ziyu , Chert Mengyuan , Hua Yonghong , Hu Qiaoying , Chen Yuanyuan , Chen Ming(Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Department of Radiology, Department of Radiation Oncology , Zhejiang Cancer Hospital, Hangzhou 310022, China ; Zhejiang University of Chinese Medicine, Hangzhou 310053, Chin)

机构地区:[1]苏州大学附属第二医院放疗科,215004 [2]浙江省肿瘤医院放射科,杭州310022 [3]浙江省肿瘤医院放疗科,杭州310022 [4]浙江中医药大学,杭州310053

出  处:《中华放射肿瘤学杂志》2018年第3期240-244,共5页Chinese Journal of Radiation Oncology

基  金:国家自然科学基金(81672971);浙江省自然科学基金(LYl6H160037);浙江省医药卫生科技计划项目(2016KYA041)

摘  要:目的 分析T3、T4期鼻咽癌患者IMRT中海马的受量,并探讨不同解剖结构受累与海马受量的相关性。方法 勾画 62例接受IMRT的鼻咽癌患者的双侧海马,并将其分为头、体、尾3部分,分析各部分照射剂量指标。结果 左、右侧海马的平均受量分别为(1127±704)、(1173±762) cGy。左侧海马头、体、尾的平均受量分别为(1732±1029)、(820±632)、(423±366) cGy (P=0.000);右侧海马头、体、尾的平均受量分别为(1985±1101)、(837±531)、(432±343) cGy (P=0.000)。海马头部受量和不同照射剂量的受照体积均明显高于体部与尾部,且头、体、尾的受量依次降低。蝶窦、筛窦及海绵窦受累与海马受量显著相关。结论 鼻咽癌患者IMRT中海马头、体、尾的受量不同,头部剂量最高。蝶窦、筛窦及海绵窦受累则提示海马受到高剂量照射,应予以重视。Objective To analyze the exposed dose of hippocampus (HC) of T3,T4 nasopharyngeal carcinoma patients treated with intensity modulated radiotherapy (IMRT). Methods The bilateral HCs were delineated and were divided into head (HH),body (HB) and tail (HT) for 62 nasopharyngeal carcinoma patients treated with IMRT.The dose parameters of HC were then analyzed. Results The mean dose of left and right HC was (1127±704) cGy,(1173±762) cGy. The mean dose of left HH,HB and HT was (1732±1029) cGy,(820±632) cGy,(423±366) cGy (P=0.000);while the mean dose of right HH,HB and HT was (1985±1101) cGy,(837±531) cGy,(432±343) cGy (P=0.000).The exposed dose and the volume exposed in different dose of HH were obviously higher than those of HB and HT.The dose parameters of HH,HB and HT decreased in turn. The involvement of sphenoid sinus,ethmoid sinus and cavernous sinus correlated with high exposed dose of HC. Conclusions The exposed dose of HH,HB and HT was different in nasopharyngeal carcinoma patients treated with IMRT.The exposed dose of HH was the highest,which should be emphasized especially. The involvement of sphenoid sinus,ethmoid sinus and cavernous sinus suggest high exposed dose of HC.

关 键 词:鼻咽肿瘤/调强放射疗法: 海马 

分 类 号:R730.55[医药卫生—肿瘤] R739.63[医药卫生—临床医学]

 

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