双侧rTMS治疗脑梗死后失语症的临床研究  

Clinical study of bilateral rTMS on patients with aphasia after cerebral infarction

作　　者：闫芳[1] 臧卫周[1] 张杰文[1] 姚勇[1] 徐军[1] 

机构地区：[1]河南省人民医院神经内科,河南郑州450003

出　　处：《中国实用神经疾病杂志》2018年第2期129-132,共4页Chinese Journal of Practical Nervous Diseases

摘　　要：目的研究双侧重复经颅磁刺激(rTMS)对脑梗死后失语症患者的疗效。方法 100例患者随机分为对照组和治疗组;对照组52例,给予常规药物治疗+语言训练,治疗组48例,在常规药物治疗+语言训练的基础上,给予双侧重复经颅磁刺激(包括低频rTMS+高频rTMS),疗程4周,以西方失语症成套测验、汉语失语成套测验对患者的失语程度及改善状况进行评定,并将2组疗效作对比。结果 AQ评分等2组治疗前后对比,差异均有统计学意义(P<0.05),治疗后2组间比较差异有统计学意义(P<0.05);总有效率治疗组81.25%,对照组55.76%,2组比较差异有统计学意义(P<0.05)。结论双侧重复经颅磁刺激(包括低频rTMS+高频rTMS)治疗脑梗死后失语症患者是安全有效的。Objective This study aimsto investigate the effect of bilateralrTMS on patients with aphasia after cerebral in- farction. Methods 100 patients were randomly divided into two groups,which are control and treatment group. 52 cases in control group were given routine drug treatment and speech training. 48 cases in treatment group were given bilateral repetitive transcranial magnetic stimulation （including low frequency rTMS ＋ high frequency rTMS） on the basis of routine drug treatment ＋ speech training. The treatment course is 4 weeks. The curative effect was compared between two groups,which is on degree of aphasia patients and improvement through Western Aphasia Battery （Western Aphasia BatteryWAB） and Chinese Aphasia Battery. ResultAQ score were compared into groups （before-treatment and after-treatment） and the difference was statistically significant （P〈0. 05）. Besides, in two groups after treatment, the difference was statistically significant （P〈0. 05）. The total effective of treatment group was 81.25% ,and the control group was 55.76% ;the two groups were statistically significant （P〈0.05）. Conclusion Bilateral repeated transcranial magnetic stimulation （including low-frequency rTMS ＋ high-frequency rTMS） is safe and effective for patients with aphasia after cerebral infarction.

关 键 词：脑梗死 失语症 双侧重复经颅磁刺激 西方失语症成套测验 汉语失语成套测验 

分 类 号：R743.33[医药卫生—神经病学与精神病学]