CXCR4和NF-κB在子宫内膜癌中的表达及其临床意义  

Expression of CXCR4 and NF-κB in Endometrial Carcinoma and their Clinical Significance

作　　者：郝秋亚 肖巍[1] 张夏华 江煜晗 李亚娟 郝彦兰 

机构地区：[1]哈尔滨医科大学附属第四医学院妇产科,黑龙江哈尔滨150000

出　　处：《现代生物医学进展》2018年第1期90-94,共5页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(201429)

摘　　要：目的:检测CXCR4和NF-κB在子宫内膜癌中的表达并探讨其在肿瘤发生发展中的作用机制。方法:用免疫组织化学SP法测定不同子宫内膜组织中CXCR4和NF-κB的蛋白质表达情况,并分析两者表达的相关性,所选标本包括20例正常子宫内膜蜡块、30例子宫内膜不典型增生石蜡标本、60例子宫内膜癌。结果:CXCR4的阳性表达率在子宫内膜癌中为73.33%、在不典型增生子宫内膜中为43.33%,在正常子宫内膜中为25.00%;NF-κB在子宫内膜癌、不典型增生子宫内膜和正常子宫内膜的阳性表达率依次为:63.33%、36.67%、15.00%,差异均具有统计学意义(P<0.05)。CXCR4和NF-κB两个因子与淋巴结有无转移、年龄、肌层浸润情况无相关性,但与癌组织分化级别相关。两个因子在子宫内膜癌中的表达具有明显的相关性(r=0.341,P=0.008)。结论:CXCR4和NF-κB在子宫内膜癌组中的阳性表达率明显升高,且两者成正相关,两个因子在诱发子宫内膜癌的发生中可能起协同作用。Objective： To explore the expression and clinical significance of CXCR4 and NF-κB in endometrial carcinoma. Meth- ods： 20 cases of normal endometriurn tissues, 30 cases of endometrial atypical hyperplasia tissues, and 60 cases of endometrial cancer tis- sues were selected as the research objects, and the protein expression of CXCR4 and NF-κB was detected with immunohistochemical technique in different tissues, and the correlation of CXCR4 and NF-κB expression was analyzed. Results： The positive expression rate of CXCR4 in endometrial carcinoma, endometrial atypical hyperplasia, normal endometium was 73.33 %, 43.33 %, 25.00 % respectively, and the positive expression rate of NF-κB was 63.33 % in endometrial carcinoma, 36.67 % in atypical hyperplasia of endometrium, and 15.00 % in normal endometrium tissues and the difference of their expression was dramaticlly statistically significant among groups （P 〈 0.05）. The expression of CXCR4 and NF-κB was independent from lymph node metastasis, age, and myometrial invasion, but had corre- lation with differentiation of tumor. In addtion, there was positive correlation between them. Conclusions： The expression of CXCR4 and NF-κB is elevated obviously in endometrial carcinoma tissues, and they are positively related, suggesting that a vital important role in the progress of endometrial carcinoma.

关 键 词：CXCR4 NF—κB 子宫内膜癌 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]