胸腺肿瘤的临床病理特征  

Clinicopathological analysis of thymus neoplasms

作　　者：徐振武[1] 许春伟[2] 徐倩[3] 张晶[1] 陈胜佳[1] 林金兰 庄武[1] 陈燕坪[2] 陈刚[2] 

机构地区：[1]福建医科大学附属福建省肿瘤医院胸部肿瘤内科,福州350014 [2]福建医科大学附属福建省肿瘤医院病理科,福州350014 [3]福建医科大学附属协和医院肿瘤科,福州350001

出　　处：《临床与病理杂志》2018年第1期61-68,共8页Journal of Clinical and Pathological Research

基　　金：国家临床重点专科建设项目(2013)~~

摘　　要：目的:探讨福建省肿瘤医院胸腺肿瘤的病理类型及年龄分布特点。方法:收集2007年1月1日至2017年8月31日病理诊断448例胸腺肿瘤,复习其临床资料、HE切片及免疫组织化学切片。按WHO(2015版)分类标准进行病理诊断及分类。结果:448例胸腺肿瘤中男性244例(54.46%),女性204例(45.54%);年龄5~83岁。胸腺瘤141例(31.47%)、胸腺癌37例(8.26%)、神经内分泌肿瘤24例(5.35%)、混合性胸腺癌1例(0.22%)、纵隔生殖细胞肿瘤43例(9.60%)、纵隔淋巴瘤53例(11.83%)、纵隔组织细胞和树突状细胞肿瘤3例(0.67%)、纵隔软组织肿瘤18例(4.02%)、骨肿瘤2例(0.45%)、神经源性肿瘤66例(14.73%)、胸腺异位性肿瘤3例(0.67%)、转移性肿瘤56例(12.50%)。结论:胸腺肿瘤类型多样,其中胸腺上皮性肿瘤的发病率占明显优势,且年龄主要集中在41~60岁,纵隔生殖细胞肿瘤和纵隔淋巴瘤虽少但不容忽视。Objective： To analyze the clinicopathological features and observe the pathological type and distribution among thymus neoplasm in Fujian Cancer Hospital. Methods： A total of 448 cases of thymus neoplasm from January 1 st 2007 to August 31 th 2017 in Fujian Cancer Hospital were collected. The clinical data, HE slides and immunohistochemistry slides were reviewed. The pathological diagnosis and classification were based on the standard of WHO（2015）. Results： Among the 448 cases, males were 244 cases（54.46%）, and females were 204 cases（45.54%）, aged from 5 to 83 years. A total of 141 cases were thymomas（31.47%）, 37 cases were thymic carcinoma（8.26%）, 24 cases were thymic neuroendocrine tumors（5.35%）, 1 case was combined thymic carcinoma（16.78%）, 43 cases were germ cell tumors of the mediastinum（9.60%）, 18 cases were mediastinal lymphoma（11.83%）, 3 cases were mediastinal histiocytic and dendritic cell tumors（0.67%）, 18 cases were soft tissue tumors of the mediastinum（4.02%）, 2 cases were bone tumors（0.45%）, 66 cases were neurogenic tumors（14.73%）, 3 cases were thymic ectopic tumor（0.67%）, and 56 cases were metastatic tumors（12.50%）. Conclusion： There are many kinds of tumors in thyma, and most of which are thymic epithelial tumors, which focus at the age of 41–60. The incidences of germ cell tumors of the mediastinum and mediastinal lymphoma are low but they should not be ignored.

关 键 词：胸腺肿瘤 胸腺瘤 临床病理 

分 类 号：R736.3[医药卫生—肿瘤]