肝脏HIFU治疗剂量学初步研究  

High Intensity Focused Ultrasound Destructive Dosage of Liver:A Preliminary Study

作　　者：熊树华[1] 刘宝琴[1] 胡凯[1] 李发琪[1] 田耘博[1] 杜永洪[1] 马平[1] 王智彪[1] 

机构地区：[1]重庆医科大学医学超声工程研究所,重庆市400010

出　　处：《中国超声医学杂志》2002年第8期572-574,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的 :探讨在直线扫描方式时 ,高强度聚焦超声 (HIFU)损伤不同深度的正常羊肝组织的治疗剂量 ,即产生单位体积凝固性坏死所需要的超声输出能量。方法 :应用频率 1.0 MHz,焦域平均声强为 5 5 0 0 W/ cm2 ,对 15头南疆黄羊距皮肤 30 mm、 4 0 mm、 5 0 mm的肝组织内行 HIFU损伤 ,损伤范围 30 mm× 10 mm× 10 mm,扫描线间距和面间距均为 5 mm。术后 3～ 7天内处死动物 ,测量凝固性坏死体积 ,观察治疗剂量与治疗深度的关系。结果 :距皮30 mm深度肝脏 HIFU治疗剂量为 (16 .6± 2 .72 ) J/ mm3,4 0 mm为 (2 8.3± 6 .37) J/ mm3,5 0 mm为 (44 .7± 3.71)J/ mm3。结论 :HIFU致肝组织的凝固性坏死有明显的量效关系 。Objective:To explore the HIFU destructive dosage of goat liver under linear scanning mode.Methods:Different depth of liver of 15 Nanjiang yellow goat were treated with HIFU of 1MHz,and average acoustic focused regional intensity 5500W/cm 2.The target region were 30mm×10mm×10mm,and the scanning gap were 5mm.To obtain the destructive volume of liver,all animal were sacrified after 3 7 days of HIFU.Results:The destructive dosage of liver under skin of 30mm,40mm,50mm depth were 16 6±2 72 J/mm 3,28 3±6 37 J/mm 3 and 44 7±3 71 J/mm 3,respectively.Conclusions:There are apparent dose response relation in liver coagulative necrosis induced by HIFU,and the value increased following with increased radiation depths under skin.

关 键 词：高强度聚焦超声 治疗剂量 肝脏 凝固性坏死 

分 类 号：R73-36[医药卫生—肿瘤]