ANGPTL3与代谢紊乱相关疾病的研究进展  

Research progress of ANGPTL3 on metabolic disorders related diseases

作　　者：张强[1] 尹卫东[1] 唐朝克[1] ZHANG Qiang, YIN Weidong, TANG Chaoke(Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hu＇nan Province, Medical Research Experiment Center, University of South China, Hu＇nan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, Chin)

机构地区：[1]南华大学心血管疾病研究所,动脉硬化学湖南省重点实验室,医学研究实验中心,湖南省分子靶标新药研究协同创新中心,衡阳421001

出　　处：《生命的化学》2018年第1期30-34,共5页Chemistry of Life

基　　金：国家自然科学基金项目(81570408)

摘　　要：血管生成素样蛋白3(ANGPTL3)是一种分泌性糖蛋白,与家族性低β脂蛋白血症、动脉粥样硬化、糖尿病等代谢紊乱疾病的发生密切相关。ANGPTL3具有调控脂质代谢和促进血管生成的功能,研究ANGPTL3与代谢紊乱相关疾病的关系,对防治相关疾病具有重要意义。Angiopoietin-like protein 3（ANGPTL3） is a secretory glycoprotein, it has closely relationship with metabolic disorders diseases, like familial combined hypobetalipoproteinemia, atherosclerosis and type 2 diabetes mellitus. It is known that ANGPTL3 palys an important role in the metabolism of lipids and angiogenesis progress. The entire understanding of ANGPTL3 intimate mechanism of action might be able to prevent metabolic disorders related diseases.

关 键 词：血管生成素样蛋白3 家族性低β脂蛋白血症 动脉粥样硬化 肥胖 糖尿病 

分 类 号：R363[医药卫生—病理学]