抑郁症患者血清IL-6水平与持续性注意力的相关性  

Association between serum IL-6 level and sustained attention in patients with major depressive disorder

作　　者：陈洁[1] 惠李[2] 张保华 叶刚 朱宏亮[2] 汤臻 李佳 唐闻捷[1] Chen Jie, Hui Li, Zhang Baohua, Ye Gang, Zhu Hongliang, Tang Zhen, Li Jia, Tang Wenjie(1.First School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325000, China ;2. Research Center of Biological Psychiatry, The Affiliated Guangfi Hospital of Soochow University, Suzhou 215137, China ;3. Department of Psychosomatic Medicine, Beijing Huilong-guan Hospital, Peking University Beijing 102200, China)

机构地区：[1]温州医科大学第一临床医学院,温州325000 [2]苏州大学附属广济医院生物精神医学研究中心,苏州215137 [3]北京大学回龙观临床医学院心身医学科,北京102200

出　　处：《中华行为医学与脑科学杂志》2018年第2期169-173,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81771439,81501160）;江苏省青年医学人才项目（QNRC2016228）

摘　　要：目的探讨抑郁症患者血清IL-6水平与持续性注意力的相关性。方法采用病例对照研究方法，通过酶联免疫吸附法（ELISA）分别检测30名抑郁症患者和30名健康受试者的血清IL-6水平，应用剑桥神经心理自动化成套测试软件（CANTAB）中快速视觉信息处理（RVP）评估所有受试者的持续性注意力。结果在调整性别、年龄、教育、吸烟和BMI之后，抑郁症患者血清IL-6水平显著高于健康受试者[（12．03±0．83）pg／ml，（2．77±0．24）pg／ml]（P〈0．01）；抑郁症患者的RVP测验总错误数和平均潜伏期均高于健康受试者[（10．20±4．44），（5．37±3．67）]（P=0．008），[（486．78±135．47）ms，（370．58±72．42）ms]（P=0．014）。抑郁症患者血清IL-6水平与RVP测验平均潜伏期呈显著正相关（r=0．46，P=0．011），而与RVP总击中数和总错误数均无相关性（P〉0．05），健康受试者血清IL-6水平与RVP测验各评分均无相关性（P〉0．05）。结论血清IL-6水平可能参与了抑郁症患者持续性注意力的损伤，并且可能影响了抑郁症的发病。Objective To examine the correlation between serum interleukin-6 （IL-6） levels and sustained attention in patients with major depressive disorder （MDD）. Methods 30 patients with MDD and 30 healthy controls were enrolled in the case-control study. Serum IL-6 levels in all subjects were assessed by sandwich enzyme-linked immunosorbent assay （ELISA）. Sustained attention in all subjects was measured respectively using rapid visual information processing（ RVP ） task in the Cambridge neuropsychological tests automated battery （CANTAB）. Results Serum IL-6 levels in patients with MDD were significantly higher than those in healthy controls after controlling for gender, age, education, smoking, and BMI （（12.03±0.83） pg/ml , （2.77±0.24） pg/ml） （P〈0.01）. RVP total misses and RVP mean latency in patients with MDD were higher than those in healthy controls after controlling for gender, age, education, smoking,and BMI（RVP total misses （10.20±4.44）, （5.37±3.67）,P= 0.008,RVP latency （486.78±135.47） ms, （370.58±72.42）ms,P= 0.014）.Serum IL-6 level were positively correlated with RVP mean latency in patients with MDD （r= 0.46,P= 0.011）. But there were no correlation between serum IL-6 level and RVP total hits and RVP total misses in patients with MDD（ P〉0.05）, and there were also no relationship between serum IL-6 levels and RVP task in healthy controls（P〉0.05）. Conclusions Serum IL-6 level may be implicated in the impairment of sustained attention in patients with MDD, and elevated IL-6 level may influence the susceptibility to MDD.

关 键 词：抑郁症 IL-6 持续性注意力 相关性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]