灵芝对前列腺癌的作用机理  

Advances in Studies on Mechanisms of Anti-prostate Cancer Propertyof Ganoderma Lucidum

作　　者：汪雯翰[1] 贾薇[1] 张劲松[1] 徐宾 杨焱[1] 王忠[2] 张赫男[1] WANG Wenhan1 , JIA Wei1 , ZHANG Jingsong1 , XU Bin1 , YANG Yan1 , WANG Zhong2 ,ZHANG Henan1(1 Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences; Key Laboratory of Resources and Utilization of Edible Fungi （South）, Ministry of Agriculture; National Engineering Research Center of Edible Fungi; National R＆D Center for Edible Fungi Processing; Key Laboratory of Agricultural Genetics and Breeding of Shanghai, Shanghai 201403, China; ZDepartment of Urology, Sixth People＇s Hospital South Campus affiliated with Shanghai Jiaotong University, Shanghai 201400, China)

机构地区：[1]上海市农业科学院食用菌研究所,农业部南方食用菌资源利用重点实验室,国家食用菌工程技术研究中心,国家食用菌加工技术研发分中心,上海市农业遗传育种重点开放实验,上海201403 [2]上海交通大学附属第六人民医院南院泌尿外科,上海201400

出　　处：《食用菌学报》2018年第1期107-112,共6页Acta Edulis Fungi

基　　金：上海市市级农口系统青年人才成长计划[沪农青字(2016)第1-14号]和上海市科技兴农重点公关项目[沪农科攻字(2016)第5-4号]

摘　　要：从诱导前列腺癌细胞凋亡、细胞周期阻滞、抑制癌血管生成和癌细胞转移、激活免疫等方面综述了灵芝(Ganoderma lucidum)对抑制前列腺癌的作用机理,为深入研究和开发以灵芝为来源的防治前列腺癌的功能性食品、保健品和药品提供科学依据。Recent advances in mechanisms of the anti-prostate cancer activity of Ganoderma lucidum were reviewed. To our knowledge, multiple machanisms act in concert to deliver the anti-prostate cancer effect. These mechanisms include induction of cancer cell apotosis, blockage of cancer cell cycle, inhibition of angiogenesis and metastasis, and activation of immune system. These findings provide bases for further research and development of G. lucidum-based functional foods, health products and theraputic agents for prevention and treatment of prostate cancer.

关 键 词：细胞凋亡 细胞周期 雄激素受体 血管生成 转移 免疫 

分 类 号：R285[医药卫生—中药学]