Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression:A Hypothesis  

作　　者：Chang LIU Bin LUO Xiao-xun XIE Xing-sheng LIAO Jun FU Ying-ying GE Xi-sheng LI Gao-shui GUO Ning SHEN Shao-wen XIAO Qing-mei ZHANG 刘畅;罗彬;谢小薰;廖兴胜;付骏;葛盈盈;李希圣;郭高水;沈宁;肖绍文;张庆梅(Department of Neurosurgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Histology and Embryology,Guangxi Medical University,Nanning 530021,China;Central Laboratory,School of Pre-Clinical Medicine,Guangxi Medical University,Nanning 530021,China;Department of Oral and Maxillofacial Surgery,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]Department of Neurosurgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [2]Department of Histology and Embryology,Guangxi Medical University,Nanning 530021,China [3]Central Laboratory,School of Pre-Clinical Medicine,Guangxi Medical University,Nanning 530021,China [4]Department of Oral and Maxillofacial Surgery,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2018年第1期19-25,共7页华中科技大学学报(医学英德文版)

基　　金：supported by grants from National Natural Science Foundation of China(No.81460382,No.81560408,No.81360371,and No.81360374);Natural Science Foundation of Guangxi(No.2016GXNSFAA380257,No.2016GXNSFBA380159,and No.2017GXNSFAA198001);Guangxi Key Laboratory of Biological Targeting Diagnosis and Treatment(No.GXSWBX201505);Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)and Ministry of Education(No.GJZ201603 and No.K2015-TKF03)

摘　　要：Cancer testis antigens(CTAs)are attractive targets for tumor immunotherapy because of their tumor-specific expression.Since more than half of confirmed CTAs are located on the X-chromosome,we asked whether there is a link between CTA expression and X-chromosomes.Recent reports have shown that reactivation of the inactive X-chromosome,known as X-chromosome reactivation(XCR),a unique phenomenon that exists in many high-risk tumors in women,can transform the expression of many X-linked genes from monoallelic to biallelic.In this review,we discuss the link between CTA and XCR with the hopes of providing some novel insights into tumor biology.

关 键 词：cancer testis antigen X-chromosome reactivation tumor immunotherapy 

分 类 号：R730.5[医药卫生—肿瘤]