不同胃内pH值对十二指肠溃疡病人胃电活动的影响  

Effect of various pH values on gastric myoelectrical activity in patients with duodenal ulcer

作　　者：杨春敏[1] 张秀荣[1] 毛高平[1] 张映辉[1] 李学甫[1] 

机构地区：[1]空军总医院消化科,北京100036

出　　处：《空军总医院学报》2000年第1期11-14,共4页Journal of General Hospital of Air Force,PLA

摘　　要：目的 :观察十二指肠溃疡病人急性抑酸后胃内 p H升高是否影响体表胃电活动。　方法 :选择 12例胃镜诊断的十二指肠溃疡活动期患者 ,并以 10例健康人作为对照。p H电极经鼻放入胃内 ,同时记录胃内 p H值和体表胃电。在空腹时 (基础状态 )、静脉注射生理盐水后 (生理盐水对照 )和静脉注射 Famotidine40 m g使胃内 p H≥ 7时 (p H≥ 7期 ) ,分别记录体表胃电30 m in。用计算机频谱分析计算胃电参数。　结果 :十二指肠溃疡病人基础状态胃电主频率、正常胃慢波百分比明显低于健康人 (P<0 .0 5 ) ;十二指肠溃疡病人在 p H≥ 7期胃电主频率、主频率不稳定系数 (DFIC)和正常胃慢波百分比显著高于生理盐水对照 (P<0 .0 5 ) ;p H≥ 7期 /基础状态的胃电主功率比 (1.87± 0 .2 4)明显高于生理盐水对照 /基础状态之比值 (1.0 2± 0 .15 ) (P<0 .0 1)。　结论 :十二指肠溃疡病人存在胃电活动异常 ,急性抑酸使胃内 p H升高可增强其胃电功率和改善胃电节律紊乱。Objective To investigate whether the increased gastric pH value induced by acute acid inhibition affects gastric myoelectrical activity. Methods 12 cases of patients with active duodenal ulcer diagnosed by gastroscopy, and 10 healthy subjects participated in the study. pH electrode was placed transnasally into stomach. pH monitoring and electrogastrography (EGG) were simultaneously recorded. EGG was recorded for 30 min in the fasting state (basic state),after intravenous saline (saline control) and in the period of gastric pH≥7 induced by intravenous Famotidine (duration of pH≥7), respectively. Power spectral analysis was applied to compute EGG parameters. Results In the basic state of the patients with active duodenal ulcer, dominant frequency and percentage of normal gastric slow wave were lower than in the healthy subjects ( P <0.05); Dominant frequency, dominant frequency instability factor and percentage of normal gastric slow wave significantly increased in the duration of pH≥7 as compared with saline control in the patents with duodenal ulcer. The ratio of EGG power(1.87±0.24) between in the duration of pH≥7 and in basic state was higher than that between in the saline control and in the basic state(1.02±0.15). Conclusions Abnormality of gastric myoelectrical activity exists in the patients with duodenal ulcer, and increased gastric pH value induced by acute acid inhibition may enhance EGG power and improve gastric dysrythmia.

关 键 词：十二指肠溃疡 胃酸 消化性溃疡 胃肠活动 胃电描记术 

分 类 号：R573.1[医药卫生—消化系统]