鼻咽癌缩小靶区三维调强放疗的疗效分析  

Three-dimensional and intensity modulated radiotherapy on narrow targeted area for nasopharyngeal carcinoma

作　　者：林琳[1] Lin Lin(Radiation Therapy Room, Yantaishan Hospital, Yantai 264025, Chin)

机构地区：[1]烟台市烟台山医院放疗室,264025

出　　处：《国际医药卫生导报》2018年第6期853-856,共4页International Medicine and Health Guidance News

摘　　要：目的探讨鼻咽癌缩小靶区三维调强放疗的临床效果。方法选择2015年2月至2016年6月本院收治鼻咽癌患者86例，按照随机数字法分为两组，每组43例，对照组实施三维适形放疗，观察组实施缩小临床靶体积三维调强放疗治疗，统计两组临床治疗效果及治疗出现的不良反应，并计算两组1年总生存率（OS）、无疾病生存率（DFS）、局部无复发生存率（LRFS）及无远处转移生存率（DMFS）。结果观察组有效率为67．4％，对照组为41．9％（P〈0．05），观察组出现不良反应，如听力下降、口干、放射性口腔黏膜炎及放射性皮炎的发生率均显著低于对照组（均P〈0．05），观察组1年总生存率、无疾病生存率、局部无复发生存率及无远处转移生存率均显著高于对照组（均P〈0．05）。结论对于鼻咽癌患者，实施缩小临崩i靶体积调强放疗相对于常规放疗，能更好地提高患者治疗效果，减少治疗并发症，延长患者生存时间，提高患者生活质量。Objective To investigate the clinical effect three-dimensional and intensity modulated radiotherapy on narrow targeted area for nasopharyngeal carcinoma. Methods 86 patients with nasopharyngeal carcinoma treated at our hospital from February, 2015 to June, 2016 were selected and divided into a control group and an observation group using random number method. The control group were treated with three-dimensional conformal radiotherapy and the observation group with three-dimensional and intensity modulated radiotherapy on narrow targeted area. The treatment effect and adverse reactions were observed in both groups, the 1 year overall survival rate （OS）, disease-free survival rate （DFS）, local recurrence-free survival rate （LRFS）, and no distant metastatic survival （DMFS）were measured. Results The effective rate was 67.4% in the observation group and 41.9% in the control group （P〈0.05）. The incidences hearing loss, dry mouth, radioactive oral mucositis, and radiation dermatitis were significantly lower and the 1-year overall survival rate, disease-free survival rate, local recurrence-free survival rate, and distant metastasis-free survival rate were significantly higher in the observation group than in the control group （all P〈0.05）. Conclusion Three-dimensional and intensity modulated radiotherapy on narrow targeted area for patients with nasopharyngeal carcinoma is more effective than routine radiotherapy and can decrease the incidence of complications, prolong the patients＇ survival time, and improve their life quality.

关 键 词：鼻咽癌 缩小靶区 三维调强放疗 

分 类 号：R730.55[医药卫生—肿瘤]