Visible Light Accelerated Vinyl C-H Arylation in Pd-Catalysis：＂ Application in the Synthesis of ortho Tetra-substituted Vinylarene Atropisomers  

作　　者：Jia Feng Bin Li Julong Jiang Mingkai Zhang Wenbai Ouyang Chunyu Li Yao Fu Zhenhua Gu 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China

出　　处：《Chinese Journal of Chemistry》2018年第1期11-14,共4页中国化学（英文版）

摘　　要：A visible light accelerated C-H functionalization reaction in palladium-catalyzed arylation of vinyl arenes with diaryliodonium salts is reported in the absence of additional photosensitizer. The kinetic isotope effect （kH/kD） was changed from 3.6 （under darkness） to 1.1 when irradiated by visible light, which indicated that the C-H functionalization step was the rate determining step under darkness and significantly accelerated by the irradia- tion of visible light. Finally the synthesis of ortho tetra-substituted vinylarene atropisomers with high enantiospecificity was realized via this protocol.A visible light accelerated C-H functionalization reaction in palladium-catalyzed arylation of vinyl arenes with diaryliodonium salts is reported in the absence of additional photosensitizer. The kinetic isotope effect （kH/kD） was changed from 3.6 （under darkness） to 1.1 when irradiated by visible light, which indicated that the C-H functionalization step was the rate determining step under darkness and significantly accelerated by the irradia- tion of visible light. Finally the synthesis of ortho tetra-substituted vinylarene atropisomers with high enantiospecificity was realized via this protocol.

关 键 词：palladium visible light C-H functionalization isotope effect ATROPISOMER 

分 类 号：TN929.52[电子电信—通信与信息系统] TQ333.2[电子电信—信息与通信工程]