ATROPISOMER

作品数：6被引量：10H指数：2
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相关领域：理学更多>>
相关期刊：《Journal of Pharmaceutical Analysis》《Science China Chemistry》《Pharmacology & Pharmacy》《Chemical Research in Chinese Universities》更多>>
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Chiral discrimination of small substituents in biaryl atropisomer construction:enantioselective synthesis of axially chiral 1-azafluorene via Ni-catalyzed[2+2+2]cycloaddition
《Science China Chemistry》2023年第11期3148-3153,共6页Jin-Huang Peng Yu-Qing Zheng Li-Gang Bai Wen-Bo Liu 
supported by the National Key Research and Development Program of China(2022YFA1502902);the National Natural Science Foundation of China(22371215,22222111,21971198);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012614);the Large-scale Instrument and Equipment Sharing Foundation of Wuhan University;China Postdoctoral Science Foundation(2022M722451)for the financial support。
Construction of axially chiral 1-azafluorenes via nickel-catalyzed[2+2+2]cycloaddition of alkynes and(o-alkynyl)benzyl nitriles is described.This strategy enables enantioselective discrimination of two sterically simi...
关键词：asymmetric catalysis [2+2+2]cycloaddition nickel catalysis ATROPISOMER HETEROCYCLE 
Atropisomer-based construction of a new perylene diimide macrocycle as visible-light photocatalyst for selective sulfide oxidation
《Chinese Chemical Letters》2022年第12期5088-5091,共4页Fei Yang Miaomiao Zhen Shanshan Wang Wei Wei Huan He Yanqing Xu 
supported by the National Natural Science Foundation of China(No.22171021);Yanjing Young Scholar Candidate Program of Capital Normal University,Capacity Building for SciTech Innovation-Fundamental Scientific Research Funds.
By using a perylene diimine(PDI)syn-atropisomer as highly preorganized precursor,we successfully constructed a visible-light-active organic macrocycle PDI-M.The formation of macrocyclic structure effectively avoids se...
关键词：Macrocycles Perylene diimine Photocatalysis ATROPISOMER Selective oxidation 
“Atropisomeric” Drugs: Basic Concept and Example of Application to Drug Development
《Pharmacology & Pharmacy》2020年第1期1-8,共8页Robert B. Raffa Joseph V. Pergolizzi Jr. Robert Taylor Jr. 
Many therapeutic drugs are racemates;i.e. they are chiral molecules consisting of “left”- and “right-handed” enantiomers (stereoisomers that are mirror images of each other, and are non-superimposable). In some ca...
关键词：ATROPISOMER CHIRALITY PHARMACOTHERAPY Drug Development NaV1.7 INHIBITOR 
Visible Light Accelerated Vinyl C-H Arylation in Pd-Catalysis：＂ Application in the Synthesis of ortho Tetra-substituted Vinylarene Atropisomers被引量：7
《Chinese Journal of Chemistry》2018年第1期11-14,共4页Jia Feng Bin Li Julong Jiang Mingkai Zhang Wenbai Ouyang Chunyu Li Yao Fu Zhenhua Gu 
A visible light accelerated C-H functionalization reaction in palladium-catalyzed arylation of vinyl arenes with diaryliodonium salts is reported in the absence of additional photosensitizer. The kinetic isotope effe...
关键词：palladium visible light C-H functionalization isotope effect ATROPISOMER 
Separation of atropisomers by chiral liquid chromatography and thermodynamic analysis of separation mechanism被引量：1
《Journal of Pharmaceutical Analysis》2017年第3期156-162,共7页Ling Zhang Yue Hu Elizabeth Galella Frank P. Tomasella William P. Fish 
In the pharmaceutical industry, the analysis of atropisomers is of considerable interest from both scientific and regulatory perspectives. The compound of interest contains two stereogenic axes due to the hindered rot...
关键词：ATROPISOMER SEPARATION CHIRAL HPLC Thermodynamic parameters Β-CYCLODEXTRIN stationary phase CHIRAL SEPARATION mechanism 
Synthesis and Langmuir-Blodgett Film Analysis of Atropisomers of “Picket Fence” Porphyrin被引量：2
《Chemical Research in Chinese Universities》2010年第5期761-767,共7页WANG Chao-wei REN Yu-jie CAO Zhen-feng CHEN Qi-bin 
Supported by the National Natural Science Foundation of China(No.20806025)
Four ＂picket fence＂ porphyrin atropisomers were respectively synthesized from the four corresponding atropisomers of meso-tetra（o-aminophenyl）porphyrin that had been chromatographed on a column eluted with petrole...
关键词：＂Picket fence＂ porphyrin ATROPISOMER Langmuir-Blodgett（LB） film meso-Tetra（o-pivalamidophenyl）porphyrin 
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