57例口腔黏膜下纤维化患者血液流变学影响因素分析  

Analysis of influencing factors of Hemorheology in 57 patients with oral submucous fibrosis

作　　者：王宏峰[1] 何芳奇 许春姣[1] 贺秀芳[1] 王苗苗[1] 张文瑞[1] WANG Hongfeng;HE Fangqi;XU Chunfiao;HE Xiufang;WANG Miaomiao;ZHANC Wenrui(Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China)

机构地区：[1]中南大学湘雅医院口腔内科,湖南长沙410008 [2]长沙市口腔医院口腔修复科,湖南长沙410004

出　　处：《口腔医学》2018年第3期241-244,共4页Stomatology

基　　金：中南大学研究生科研创新项目(2016zzts517)

摘　　要：目的通过检测口腔黏膜下纤维化(oral submucous fibrosis,OSF)患者血液流变学,分析吸烟和血脂等潜在因素与血液流变学的关系,以探讨血液流变学在OSF发病中的作用。方法选取57例临床及病理诊断为OSF中期的门诊患者为观察组,均无吸烟习惯的20例健康体检者为对照组,分别检测不同切变下的全血粘度、血浆粘度、红细胞压积、红细胞聚集指数和刚性指数,检测血浆中甘油三酯及胆固醇含量,并按照患者吸烟情况以及甘油三酯、胆固醇值进行亚组分析。结果 57例OSF患者全血低、中、高切粘度及红细胞压积增高者分别有38例(66.7%)、33例(57.9%)、22例(38.6%)和38例(66.7%),显著高于对照组,差异有统计学意义(P<0.01);血浆粘度、红细胞聚集指数和刚性指数虽无异常者,但相较于对照组差异显著(P<0.05);OSF各亚组分析中,吸烟组全血低切粘度、血浆黏度及红细胞压积高于不抽烟组,胆固醇增高组全血中、高切粘度及红细胞压积高于胆固醇正常组,差异均有统计学意义(P<0.05)。结论 OSF患者血液粘滞度偏高,抽烟和胆固醇含量可加剧患者血液高粘滞状态,提示戒烟和低脂饮食,并结合活血化瘀药物,对缓解OSF患者局部微循环障碍可能具有一定作用,有待进一步研究揭示。Objective To investigate the changes of hemorheology in patients with oral submucous fibrosis, and to analyze the relationship between the potential factors such as smoking and blood lipid and hemorheology, to explore the role of hemorheology in the pathogenesis of OSF. Methods A total of 57 clinic patients linical and pathological diagnosis of middle OSF were the content of blood viscosity with different shear, plasma viscosity, hematocrit, erythrocyte aggregation index and rigidity index, serum triglyceride （TG） and cholesterol （TC） , and the subgroup analysis was applied according to smoking or not , TG and TC content. Results Patients pos- sessing low, medium, high shear viscosity and hematocrit in all 57 patients with OSF were 38 cases （66.7%）, 33 cases （57.9%）, 22 cases （ 38.6% ） and 38 cases （ 66.7% ） respectively, significantly higher than the control （P〈0.01）. Plasma viscosity, erythrocyte ag- gregation index and rigidity index were not abnormal, but they had significant difference compared with the controls （P〈0.05）. In the subgroup analysis of OSF, the low shear blood viscosity, plasma viscosity and hematocrit of smoking group were higher than non-smok- ing group.The medium shear viscosity, the high shear viscosity and hematocrit in TC Increased Group were higher than the TC Normal Group. The differences were statistically significant （P〈 0.05 ）. Conclusion The blood viscosity of patients with OSF is high, and smoking and cholesterol can aggravate high blood viscosity state, suggesting that smoking cessation and low-fat diet combining with blood circulation drugs have certain guiding significance to alleviate the local microcirculatory disorders in OSF patients.

关 键 词：口腔黏膜下纤维化 血液流变学 胆固醇 吸烟 

分 类 号：R781.5[医药卫生—口腔医学]